羟基磷灰石/纤维素复合材料在骨组织工程中的研究进展

doi:10.11896/cldb.19010012

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Abstract Since hydroxyapatite composites were used as biomedical substitutes, the raw materials and preparation technology of hydroxyapatite composites have been continuously optimized, and composites with properties close to natural bone have been prepared. However, there are still many deficiencies in the hydroxyapatite composite material, such as poor compatibility and poor bone integration due to the failure of the compressive strength and elastic modulus to meet the requirements of natural bone,which severely hinders its development as a bone substitute. Hydroxyapatite/cellulose composites not only have the characteristics of both, but also have excellent synergistic properties, which make them more suitable for bio-tissue engineering materials. Compared with traditional bone substitutes, HAP/cellulose composites have significant improvements in mechanical properties, biological activity, biocompatibility, biodegradability and other aspects, and have better osteogenic activity, which has basically met the requirements of ideal scaffold materials for tissue engineering applications.
Cellulose nanocrystal, bacterial nanocellulose, carboxymethyl cellulose (CMC), etc. have been found to be satisfactory as the base material for preparation of the hydroxyapatite composite material. However, there are differences in properties between different cellulose/hydroxyapatite composites. Some nanocomposites have low compressive strength, only (1.57±0.09)MPa/cm³, but some compressive strength and modulus of nanocomposites can be close to natural bones. Therefore, in recent years, in addition to constantly optimizing the preparation process, researc-hers have been trying to select suitable cellulose, and have made great progress. At present, researchers have found that the compressive strength and modulus of CMC/gelatin/HAP nanocomposites are similar to those of human cancellous and cortical bones, and they also promote high alkaline phosphatase activity and extracellular mineralization of cells. It can be used as a regenerative bone graft material for the main bearing area.
In this paper, the characteristics of HAP and cellulose are introduced. The preparation methods and the recent application and development of various HAP/cellulose composites are reviewed, and the properties of composites are also discussed, and the study and prospects of the hydroxyapatite/cellulose composites materials are presented. And we hope to provide a reference for the preparation of bone substitute materials with better properties.

Key words： hydroxyapatite cellulose composites bone tissue engineering

Published: 30 September 2019

CLC number:

TQ170

Fund:This work was financially supported by the National Natural Science Foundation of China (21766016,21566014,51364023), Reserve Talents Program of Yunnan Province(2015HB014).

About author:: Yanru Jin received her B.E. degree in chemical technology from Kunming University of Science and Technology in 2016. She is currently pursuing her master’s degree at the Faculty of Chemical Engineering, Kunming University of Science and Technology under the supervision of Prof. Qingming Jia and prof. Shaoyun Shan. The research has focused on chemical environmental protection materials.
Shaoyun Shan is a professor and doctoral supervisor at the Faculty of Chemical Engineering of Kunming University of Science and Technology. At the same time, she is also a reserve talent for young and middle-aged academic and technical leaders in Yunnan Province, and the school head of mineral ecological environment functional ceramic materials. In recent years, her research interests are the field of chemical environmental protection, including a novel magnetic MIL-101(Fe)/TiO₂ composite, and CaO-based sorbent derived from lime mud and bauxite tailings for cyclic CO₂ capture.

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Cite this article:

JIN Yanru,JIA Qingming,SHAN Shaoyun. Research Progress of Hydroxyapatite/Cellulose Composites in Bone TissueEngineering[J]. Materials Reports, 2019, 33(23): 4008-4015.

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http://www.mater-rep.com/EN/10.11896/cldb.19010012 OR http://www.mater-rep.com/EN/Y2019/V33/I23/4008

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