钆基稀土纳米颗粒的制备及应用研究进展

doi:10.11896/cldb.18070118

Abstract
Figure/Table
References
Related Citation (14)

Download:

Full Text ( PDF ) (5507KB)
Export: BibTeX | EndNote (RIS)

Abstract In recent years, rare earth elements have attracted extensive attention due to their special 4f electronic structure, relatively large atomic number and unique optical and magnetic properties. Thus, they have been widely adopted in the preparation of rare earth based nanoparticles, especially, the preparation and physicochemical properties of gadolinium-based nanoparticles. The studies demonstrated that the rare earth-based nanomaterials are easily doped with other rare earth as well as metal ions, with good stability, low phonon energy, and a large neutron absorption cross-section, which have been extensively applied in the fields of luminescence, biological and medicine.
Researchers have obtained rare earth nanomaterials with various morphologies and microstructures via different preparation methods, for improving their luminescence properties, relaxation properties, drug carrying properties and targeting. so the nanoparticles can be better applied in different fields, such as luminescence, imaging, medical treatment and so on. The gadolinium oxide nanoparticles is mostly prepared by liquid phase method since the operation has the characteristics of simple operation, particle size is controllable and the dispersibility of nanoparticles is good.
The rare earth luminescent materials can absorb or emit electromagnetic wave radiation of various wavelengths from ultraviolet to infrared regions. Therefore, to study the influence of different rare earth ions doped gadolinium oxide on their luminescence performance, researchers have also utilized the co-doping of various rare earth ions, rare earth ions and metal ions to achieve the goal of regulating the luminescence, ameliorating the color saturation and the luminescence intensity by adjusting the doping ratio.
Gadolinium ion is used as a magnetic resonance contrast agent on account of its seven unpaired electrons. Currently, the most commonly used negative contrast agent in clinic is mainly based on nano-iron oxide, and the positive contrast agent is mainly based on gadolinium-diethylenetriamine pentaacetic(Gd-DTPA). There are few investigations on negative contrast agents since the nano-iron oxide imaging exists a series of problems, such as low signal intensity, dark image and artifacts Gadolinium oxide has higher density of magnetic particles than that of the Gd-DTPA, therefore, the recent research hotspots have been revolved round improving the relaxation properties of gadolinium oxide nanomaterials through optimizing the preparation process, and combining the fluorescence and magnetism of gadoliniumoxide nanomaterials to realize the dual mode detection function of optical magnetic resonance imaging (MRI). Besides, high atomic number of gadolinium can act as a radiosensitizer as well, which may enhance the sensitivity of tumor cells to radiotherapy. Hafnium and bismuth are both sensitizers with radiosensitizating potential as well as the gold, furthermore, the Gd-based sensitizers combining MRI can realize image-guided radiation therapy. Moreover, gadolinium has attached importance to the application of shielding materials due to its higher ray absorption properties than that of the lead.
This paper compares several main preparation methods ofgadolinium oxide nanoparticles and their characteristics. The applications of gadoli-nium oxide nanoparticles in luminescent materials, medical treatment and shielding materials are briefly described and finally the existing problems and development directions of gadolinium oxide nanoparticles are pointed out.

Key words： gadolinium oxide nanoparticles luminescence magnetic resonance radiosensitizer bioprobe

Published: 14 June 2019

CLC number:

O482.31

Fund:This work was supported by Guizhou Provincial Department of Education Engineering Research Center Project (Guizhou Jiaohe KY word [2017] 016); Guizhou Provincial Department of Education Science and Technology Talent Growth Project (Guizhou Jiaohe KY word [2017] 238); Guizhou Provincial Department of Education Innovation Group Major Research Project (2016021).

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	HU Yanyan
	YANG Chunlin
	QIAO Huina
	OU Meigui

Cite this article:

HU Yanyan,YANG Chunlin,QIAO Huina, et al. Research Progress in the Preparation and Application of Gadolinium-based Nanoparticles[J]. Materials Reports, 2019, 33(13): 2243-2251.

URL:

http://www.mater-rep.com/EN/10.11896/cldb.18070118 OR http://www.mater-rep.com/EN/Y2019/V33/I13/2243

Xu J Q, Chen Y P, Wang H X. Journal of Zhengzhou University of Light Industry (Natural Science), 2004, 19(1),1 (in Chinese).徐甲强, 陈玉萍, 王焕新.郑州轻工业学院学报:自然科学版, 2004, 19(1), 1.2 Feng L F, Zhang X. Zhejiang Journal of Preventive Medicine, 2013, 25(9), 32 (in Chinese).冯玲芳, 张幸. 浙江预防医学, 2013, 25(9), 32.3 Mccarthy J R, Weissleder R. Advanced Drug Delivery Reviews, 2008, 60(11), 1241.4 eljka A, Lojpur V,Nikolic＇ M G,et al. Journal of Luminescence, 2014, 145, 466.5 Park J Y, Baek M J, Choi E S, et al. ACS Nano, 2009, 3(11), 3663.6 Cho H K, Cho H J, Lone S, et al. Journal of Materials Chemistry, 2011, 21(39), 15486.7 Luan D. Preparation and properties of Gd2O3∶Eu and Fe3O4@ Gd2O3∶Eu nanolabeled particles, Master's Thesis, Northeastern University, China, 2008 (in Chinese).栾丹.Gd2O3∶Eu和Fe3O4@ Gd2O3∶Eu纳米标记粒子的制备与性能研究. 硕士学位论文.东北大学, 2008.8 Liu G X, Bai H Y, Dong X T, et al. Journal of the Chinese Ceramic Society, 2011, 39(9), 1411(in Chinese).刘桂霞, 白海英, 董相廷, 等.硅酸盐学报, 2011, 39(9), 1411.9 Mowat P, Mignot A, Rima W, et al. Journal of Nanoscience and Nanotechnology, 2011, 11(9), 7833.10 Dr C F, Jungk H O. Angewandte Chemie International Edition, 2001, 40(2), 359.11 Bazzi R, Flores M A, Louis C, et al. Journal of Colloid & Interface Science, 2004, 273(1), 191.12 Flores González M A, VillanuevaIbáez M J, Santiago L D, et al. Superficies Y Vacio, 2006, 19(2), 23.13 Hao J. Preparation technology of ultra-small Gd2O3 nanoparticles and evaluation of MRI contrast enhancement. Master's Thesis, Wuhan University of Technology, China, 2014 (in Chinese).郝晶. 超小Gd2O3纳米粒子的制备技术及MRI造影增强效果评价. 硕士学位论文,武汉理工大学, 2014.14 Cai S H, Ou M G, Yang C L. Materials Review B:Research Papers, 2013, 27(4), 21 (in Chinese).蔡少韩, 欧梅桂, 杨春林. 材料导报:研究篇, 2013, 27(4), 21.15 Yang C L, Zhu Q W, Ou M G. New Chemical Materials, 2017(3), 199 (in Chinese).杨春林,朱琦玮,欧梅桂.化工新型材料, 2017(3), 199.16 Ou M G, Cai S H, Yang C L. Chinese Journal of Luminescence, 2013, 34(5), 554 (in Chinese).欧梅桂,蔡少韩,杨春林, 等.发光学报, 2013, 34(5), 554.17 Ou M G, Yang C L, Cai S H, et al. Advanced Materials Research, 2013, 813, 323.18 Zhu Q W. Preparation and luminescence properties of rare earth core-shell nanoparticles. Master's Thesis, Guizhou University, China, 2015(in Chinese).朱琦玮.稀土核壳结构纳米颗粒的制备及发光性能研究.硕士学位论文,贵州大学, 2015.19 Tian G, Gu Z J, Liu X X, et al. Journal of Physical Chemistry C, 2011, 115(48), 23790.20 王军, 李旺, 宁爱凤, 等.中国专利,201310013691.4, 2014.21 Chen S S, Chen X H, Ding M J, et al. Journal of the Chinese Ceramic Society, 2007, 35(2), 178(in Chinese).陈思顺,陈新华,丁明洁,等.硅酸盐学报, 2007, 35(2), 178.22 Liu S W. Preparation and luminescence properties of Y2O3∶Tb3+ and Gd2O3∶Tb3+ nanomaterials. Master's Thesis, Hunan University, China, 2011 (in Chinese).刘少武.Y2O3∶Tb3+和Gd2O3∶Tb3+纳米材料的制备及发光性能研究.硕士学位论文,湖南大学,2011.23 Zhai Y Q, Liu Y H, You Z J, et al. Journal of Synthetic Crystals, 2011, 40(6), 1440(in Chinese).翟永清, 刘亚红, 游志江, 等.人工晶体学报, 2011, 40(6), 1440. 24 Liu Y H. Preparation and properties of Gd2O3 based rare earth luminescent materials with special morphology of lanthanum and cerium ions. Master's Thesis, Hebei University, China, 2012 (in Chinese).刘亚红.铕、镝离子掺杂的特殊形貌Gd2O3基稀土发光材料的制备及性质研究.硕士学位论文,河北大学, 2012.25 Zhu W Q, Chen H J, Xing X P, et al. Journal of Xi'an Polytechnic University, 2014(2), 187(in Chinese).朱文庆,陈浩军,邢西萍,等.西安工程大学学报, 2014(2), 187.26 La L B T, Leong Y, Watts H P, et al. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2016, 506, 13.27 Ranjan S K,Soni A K,Rai V K. Materials Today: Proceedings, 2017, 4(4), 5593.28 Heiba Z K,Mohamed M B. Journal of Molecular Structure, 2015, 1102, 135.29 Jia Y,Song Y,Bai Y,et al. Luminescence, 2011, 26(4), 259.30 Li D,Qin W P,Aidilibike T,et al. Journal of Alloys and Compounds, 2016, 675, 31.31 Liu G X, Wang J X, Dong X T, et al. Journal of Inorganic Materials, 2007, 22(5), 803(in Chinese).刘桂霞, 王进贤, 董相廷, 等. 无机材料学报, 2007, 22(5), 803.32 Bai H Y, Liu G X, Dong X T, et al. Journal of the Chinese Chemical Society, 2011, 69(7), 783(in Chinese).白海英, 刘桂霞, 董相廷, 等. 化学学报, 2011, 69(7), 783.33 Zou Y. Novel multicolor labeling and fluorescence imaging markers. Master's Thesis, Jinan University, China, 2014 (in Chinese).邹阳. 新型多色标记和荧光成像标记物研究.硕士学位论文,暨南大学, 2014.34 Huang F, Chen D Q. Journal of Materials Chemistry C, 2017, 5(21), 5176.35 Riegler J, Wells J A, Kyrtatos P G, et al. Biomaterials, 2010, 31(20), 5366.36 Liu Y P. Synthesis and cell imaging of magnetic rare earth fluorescent multifunctional nanoparticles. Master's Thesis, Huazhong University of Science and Technology, China, 2013 (in Chinese).刘玉萍. 磁性稀土荧光多功能纳米颗粒的合成及细胞成像研究.硕士学位论文,华中科技大学, 2013.37 Liu Z,Ren J S,Qu X G. Scientia Sinica Chimica, 2017, 47(2), 155.38 Xu L. Study on structural evolution and electromagnetic properties of cerium oxide clusters. Master's Thesis, Southwest University, China, 2013 (in Chinese).许琳. 氧化钆团簇的结构演化和电磁性质的研究.硕士学位论文, 西南大学, 2013.39 Liang G H. Development of a novel MRI contrast agent and a new molecular diagnostic method based on magnetic relaxation switch technology. Master's Thesis, Fudan University, China, 2013 (in Chinese).梁国海.新型MRI造影剂的研制及基于磁性弛豫开关技术的分子诊断新方法研究.硕士学位论文,复旦大学, 2013.40 Branka B S, Vukoman J, Du an M, et al. Journal of Nanoparticle Research, 2014, 16(10), 2663.41 Fortin M A, Rodrigo M P J, S derlind F, et al. Nanotechnology, 2007, 18(39), 395501.42 Jie F, Prashant C, Liu X L, et al. Biomaterials, 2014, 35(5), 1636.43 Detappe A, Kunjachan S, Sancey L, et al. Journal of Controlled Release, 2016, 238, 103.44 Luchette M, Korideck H, Makrigiorgos M, et al. Nanomedicine: Nanotechnology, Biology and Medicine, 2014, 10(8), 1751.45 Miladi I, Aloy M T, Armandy E, et al. Nanomedicine Nanotechnology Biology & Medicine, 2015, 11(1), 247.46 Hainfeld J F, Dilmanian F A, Zhong Z, et al. Physics in Medicine & Biology, 2010, 55(11), 3045.47 Li Y, Liu W, Wang J J, et al. Progress in Modern Biomedicine, 2016, 16(5), 986 (in Chinese).李勇, 刘祎, 王建杰, 等. 现代生物医学进展, 2016, 16(5), 986.48 Porcel E, Tillement O, Lux F, et al. Nanomedicine, 2014, 10(8), 1601.49 Rima W, Sancey L, Aloy M T, et al. Biomaterials, 2013, 34(1), 181.50 tefaníková L, Porcel E, Eustache P, et al. Cancer Nanotechnology, 2014, 5(1), 6.51 tefaníková L, Lacombe S, Salado D, et al. Journal of Nanobiotechnology, 2016, 14(1), 63.52 Porcel Erika, Tillement O, Lux F, et al. Nanomedicine: Nanotechnology, Biology and Medicine, 2014, 10(8), 1601.53 He Y Y. Journal of International Neurology and Neurosurgery, 2017, 44(1), 68(in Chinese).何永跃.国际神经病学神经外科学杂志, 2017, 44(1), 68.54 Siegel R, Naishadham D, Jemal A. CA: A Cancer Journal for Clinicians, 2013, 63(1), 11.55 黄忠兵.中国专利,201610531117.1, 2016.56 Cui D T. Preparation of bellowin-labeled cerium oxide nanoparticles and its targeted imaging experiment. Master's Thesis, Southern Medical University, China, 2015 (in Chinese).崔丹婷.铃蟾肽标记的氧化钆纳米微粒的制备及其靶向成像实验研究.硕士学位论文,南方医科大学,2015.57 Zhang S C. Modification of cerium oxide and preparation of cerium oxide/polyethylene shielding material. Master's Thesis, Xibei University, China, 2015 (in Chinese).张圣辰.氧化钆的改性及氧化钆/聚乙烯屏蔽材料制备.硕士学位论文,西北大学,2015.58 Chen J, Huang H L, Qian Y Y, et al. Sichuan Rare Earth, 2008(3), 14 (in Chinese).陈俊,黄宏林,钱玉英,等. 四川稀土, 2008(3), 14.59 Wang H B. Preparation and properties of cerium oxide/polyetheretherketone composites.Master's Thesis, Jilin University, China, 2013 (in Chinese).王海滨. 氧化钆/聚醚醚酮复合材料的制备及性能研究.硕士学位论文, 吉林大学, 2013.60 Zhang Y B. Preparation and properties of cerium oxide neutron absorbing materials. Master's Thesis, Shandong University, China, 2017 (in Chinese).张羽白. 氧化钆中子吸收材料制备及性能研究.硕士学位论文, 山东大学, 2017.