Synthesis and Drug Delivery Properties of Nano Metal-organic Framework ZIF-90
Hong DONG,Xiaojun SUN,Xin ZHANG,Doudou YANG,Xueliang WANG,Fengming ZHANG
Key Laboratory of Green Chemical Engineering and Technology of College of Heilongjiang Province, College of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin 150040
Metal organic frameworks are a kind of porous crystalline material with periodic multidimensional network structure formed by metal ions and organic ligands self-assembly process, which have been applied widely in catalysis, sensing, storage of gas and medicine, etc. The ZIF-90 nanostructured material with particle sizes below 300 nm was prepared. The structure of the metal-organic framework was characterized by FTIR and XRD. Scanning electron microscopy (SEM) characterized the morphology and particle size. The results of loading and releasing anti-cancer drug 5-fluorouracil on ZIF-90 nano-drug carrier showed that the loading ability of the material was up to 1.245 g/g, and the release rate was over 95%. The stability of the drug carrier at different pH showed that the drug carrier could rapidly release the drug with the skeletal collapse in the acidic condition of the tumor cells, therefore, ZIF-90 has potential ability of the tumor to target the drug delivery.
Beck J S, Vartuli J C, Roth W J , et al. A new family of mesoporous molecular-sievesprepared with liquid-crystal templates[J]. Journal of the American Chemical Society, 1992,114(27):10834.
2
Tang M Y, Geng K S . Polymer slow release material[J]. New Chemical Materials, 1998,26(9):26(in Chinese).
3
唐明义, 耿奎士 . 高分子药物缓释材料[J]. 化工新型材料, 1998,26(9):26.
4
Dong Y J, Li Y J, Lin H , et al. Research progress of metal organic skeleton as drug carrier[J]. Heilongjiang Medical, 2014,27(5):1032(in Chinese).
4 Guan Y Q,Qiu L L,Liao R X,et al. Advances in polymer drug research[J].Journal of South China Normal University (Natural Science Edition), 2005(2):125(in Chinese).
Zhou H C, Kitagawa S . Metal-organic frameworks (MOFs)[J]. Chemical Society Reviews, 2014,43(16):5415.
9
Zhang J, Kuo C H, Chou L Y , et al. Optimized metal organic-framework nanospheres for drug delivery:Evaluation of small-molecule encapsulation[J]. ACS Nano, 2014,8(3):2812.
10
Christopher G J, Vitalie S, Marissa A C , et al. Versatile synjournal and fluorescent labeling of ZIF-90 nanoparticles for biomedical applications[J]. ACS Applied Materials, 2016,8:7623.
11
8 Cai J L,Li S,Zhou C H,et al.Imidazole anti-cancer drug research progress[J].Chinese Journal of New Drugs, 2009(7):598(in Chinese).
Lo W S, Liu S M, Wang S C , et al. A green and facile approach to obtain 100 nm zeolitic imidazolate framework-90 (ZIF-90) particles via leveraging viscosity effects[J]. RSC Advances, 2014,4:52883.
14
Shieh F K, Wang S C, Leo S Y , et al. Water-based synjournal of zeolitic imidazolate framework-90 (ZIF-90) with a controllable particle size[J]. Chemistry A European Journal, 2013,4:1.
15
11 Yang B C,Jiang Y D,Qin X J,et al.Growth and in vitro release of antitumor drugs in metal organic skeleton[J].Chemical Journal of Chinese Universities, 2012(1):26(in Chinese).
Ghanashyam A, Crystal S S, Kumar V , et al. A study of drug release from homogeneous PLGA microstructures[J]. Nanomedicine and Drug Delivery, 2010,146(2):201.
20
Sun C Y, Qin C, Wang X L, at al . Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle[J]. Dalton Transactions, 2012,41:6906.
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2018, Vol. 32 
