Abstract: The amphiphilic cyclic-poly(ε-caprolactone)-b-poly(N-vinylpyrrolidone) copolymer (cyclic-PCL-b-PVP) was synthesized via atom transfer radical polymerization (ATRP) and click chemistry. The structure, molecular weight and molecular weight distribution of the copolymer were characterized by FT-IR, 1H-NMR, GPC respectively. The thermodynamic properties and the hydrophilicity of the copolymer were studied by TGA and contact angle measurement. Our results indicated an evidently higher thermal stability and a different hydrophilicity of the cyclic copolymer compared with linear-PCL-b-PVP.
1 Yamamoto T, Tezuka Y. Topological polymer chemistry: A cyclic approach toward novel polymer properties and functions [J].Polym Chem,2011,2(9):1930. 2 Wan X J, Liu T, Liu S Y. Synthesis of amphiphilic tadpole-shaped linear-cyclic diblock copolymers via ring-opening polymerization directly initiating from cyclic precursors and their application as drug nanocarriers [J]. Biomacromolecules,2011,12(4):1146. 3 Shi G Y, Pan C Y. Synthesis of well-defined figure-of-eight-shaped polymers by a combination of ATRP and click chemistry[J]. Macromol Papid Commun,2008,29:1672. 4 Luca A C D, Stevens J S, Schroeder S L M, et al . Immobilization of cell-binding peptides on poly-ε-caprolactone film surface to biomimic the peripheral nervous system [J].J Biomedical Mater Res A,2013,101(2):491. 5 Labet M, Thielemans W. Synthesis of polycaprolactone: A review [J]. Chem Soc Rev,2009,38(12):3484. 6 Hajar S, et al. In vivo biocompatibility and biodegradation of 3D-printed porous scaffolds based on a hydroxyl-functionalized poly (ε-caprolactone) [J]. Biomaterials,2012,33(17):4309. 7 Zhu Z S, Li Y, Li X L, et al. Paclitaxel-loaded poly-(N-vinylpyrrolidone)-b-poly(ε-caprolactone)[J]. J Controlled Release,2010,142(3):438. 8 Bartolozzi I, Solaro R, Schacht E, et al. Hydroxyl end-capped macromers of N-vinyl-2-pyrrolidinone as precursors of amphiphilic block copolymers [J]. Eur Polym J,2007,43(11):4628. 9 Luo L B, Ranger M, Lessard D G, et al. Novel amphiphilic diblock copolymer of low molecular weight poly(N-vinylpyrrolidone)-block-poly(D,L-lactide): Synthesis, characterization and micellization[J]. Macromolecules,2004,37(11):4008. 10 Persenaire O, Alexandre M, Dege′e P, et al. Mechanism and kine-tics of thermal degradation of poly (ε-caprolactone) [J]. Biomacromolecules,2001,2(1):288.
渝公网安备50019002502923号 版权所有：《材料导报》编辑部
2017, Vol. 31 
