金属基纳米材料在口腔感染性疾病抗菌领域中的最新研究

doi:10.11896/cldb.25020165

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Abstract The oral microbiota, colonizing a unique microenvironment, is an important component of the human microecological system. Disruption of the oral microecological balance significantly increases the expression of microbial virulence factors and alters metabolites, increasing the incidence of oral infectious diseases such as caries, endodontics, periapical disease, and periodontitis. In recent years, cutting-edge research in the field of biomedical materials has highlighted the potential of nanomaterials by virtue of their unique characteristics. Metal-based nanomaterials in particular have demonstrated excellent antimicrobial properties due to their unique advantages of ultra-small particle size, large surface area, and effective surface ligands. Meanwhile, in order to solve the increasingly serious problem of antibiotic resistance, metal-based nanomaterials, as a new type of antimicrobial agent, have been shown a great potential for the regulation of oral microecology, the prevention and treatment of oral infectious diseases. This summary reviews the classification, antimicrobial properties, antimicrobial mechanisms, and the latest research on metal-based nanomaterials in oral infectious diseases, aiming to provide a theoretical basis for the prevention and treatment of such diseases, and providing a reference for the clinical translation of metal-based nanomaterials.

Key words： metal-based nanomaterial antibacterial mechanism caries endodontics periapical disease periodontitis peri-implant disease

Published: 25 April 2026 Online: 2026-05-06

CLC number:	R459.9
	R318.08
	R780.1

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	Articles by authors
	LIU Yan
	YANG Ruixuan
	LIU Xiaomeng
	LI Qiyan
	PAN Jie

Cite this article:

LIU Yan,YANG Ruixuan,LIU Xiaomeng, et al. The State of the Art of Metal-based Nanomaterials for Oral Infectious Diseases[J]. Materials Reports, 2026, 40(8): 25020165-7.

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https://www.mater-rep.com/EN/10.11896/cldb.25020165 OR https://www.mater-rep.com/EN/Y2026/V40/I8/25020165

1 Baker J L, Mark Welch J L, Kauffman K M, et al. Nature Reviews Mic-robiology, 2024, 22(2), 89.
2 Van Holm W, Carvalho R, Delanghe L, et al. NPJ Biofilms Micro-biomes, 2023, 9(1), 3.
3 Zhao X, Li B, Zhang W, et al. Topics Current Chemistry(Cham), 2023, 381(6), 34.
4 Brown T D, Habibi N, Wu D, et al. ACS Biomaterials Science Engineering, 2020, 6(9), 4916.
5 Zhang S, Kong N, Wang Z, et al. Chemical Society Reviews, 2024, 53(8), 3656.
6 Deng B, Liu S, Wang Y, et al. Advanced Materials, 2024, 36(6), e2306081.
7 Badrigilan S, Heydarpanahi F, Choupani J, et al. International Journal of Nanomedicine, 2020, 15, 7079.
8 Barik P, Mondal S. Nanoscale, 2025, 17(17), 10433.
9 Sun X, Zhou X, Shi X, et al. Nature Biomedical Engineering, 2024, 8(9), 1073.
10 Hassanen E I, Khalaf A A, Tohamy A F, et al. International Journal of Nanomedicine, 2019, 14, 4723.
11 Lewinski N A, Avrutin V, Izadi T, et al. Toxicology Research (Camb), 2018, 7(5), 754
12 Alavi M, Kamarasu P, McClements D J, et al. Advances In Colloid Interface Science, 2022, 306, 102726.
13 Wang I J, Chen Y C, Su C, et al. Journal Aerosol Medicine and Pulmonary Drug Delivery, 2021, 34(5), 293.
14 Maher C, Hassan K A. mBio, 2023, 14(6), e0120523.
15 Klaenhammer T R. Annual Review of Food Science Technology, 2019, 10, 1.
16 Neuhaus F C, Baddiley J. Microbiology and Molecular Biology Reviews, 2003, 67(4), 686.
17 Yu Z, Lepoitevin M, Serre C. Advanced Healthcare Materials, 2025, 14(8), e2402630.
18 Silver L L. Bioorganic Medicinal Chemistry, 2016, 24(24), 6379.
19 Luo T Y, Gu Y, Qin X F, et al. Chinese Tissue Engineering Research, 2023, 27 (21), 3407(in Chinese).
罗廷炎, 顾瑜, 秦晓飞. 中国组织工程研究, 2023, 27(21), 3407.
20 Zhang W, Wu Y, Liu L, et al. Journal of Materials Chemistry B, 2021, 9(25), 5092.
21 Huo S, Jiang Y, Gupta A, et al. ACS Nano, 2016, 10(9), 8732.
22 Haghniaz R, Rabbani A, Vajhadin F, et al. Jouranal of Nanobiotechnology, 2021, 19(1), 38.
23 Kamkaew A, Lim S H, Lee H B, et al. Chemical Society Reviews, 2013, 42(1), 77.
24 Jiang J, Lv X, Cheng H, et al. Acta Biomaterialia, 2024, 177, 1.
25 Liu J, Tian L, Zhang R, et al. ACS Applied Materials Interfaces, 2018, 10(50), 43493.
26 Song M Y, Jurng J, Park Y K, et al. Journal of Hazardous Materials, 2016, 318, 247.
27 Zhang G, Pan J, Dong X, et al. Colloids Surfaces B Biointerfaces, 2024, 238, 113923.
28 Cafarelli A, Marino A, Vannozzi L, et al. ACS Nano, 2021, 15(7), 11066.
29 Li S L, Dong H L, Hou H Y, et al. International Journal of Biological Macromolecules, 2024, 258(Pt 2), 129120.
30 Dediu V, Ghitman J, Gradisteanu P G, et al. International Journal of Molecular Sciences, 2023, 24(11), 9375.
31 Navarro G, Gómez-Autet M, Morales P, et al. Pharmacological Research, 2024, 208, 107363.
32 Mutalik C, Lin I H, Krisnawati D I, et al. International Journal of Nanomedicine, 2022, 17, 6821.
33 Armendariz O M, Quintero Y, Llanquilef A, et al. Materials (Basel), 2019, 12(13), 2081.
34 Lin Y, Betts H, Keller S, et al. Chemical Society Reviews, 2021, 50(18), 10346.
35 Godoy-Gallardo M, Eckhard U, Delgado L M, et al. Bioactive Materials, 2021, 6(12), 4470.
36 Zhao J, Wu S, Huang Y, et al. BMC Oral Health, 2024, 24(1), 293.
37 Meran Z, Besinis A, De Peralta T, et al. Journal of Biomedical Materials Research B:Applied Biomaterials, 2018, 106(3), 1038.
38 Wang S, Fang L, Zhou H, et al. Dental Materials, 2024, 40(2), 179.
39 Cifuentes-Jiménez C, Bolaños-Carmona M V, Enrich-Essvein T, et al. International Journal of Biological Macromolecules, 2024, 268(Pt 1), 131676.
40 Chang L, Gan R, Huang X, et al. Scientific Reports, 2024, 14(1), 29027.
41 Kongyodsueb P, Poolthong S, Chumprasert S, et al. Australian Dental Journal, 2024, 69(1), 56.
42 Estedlal T, Omrani L R, Abdi K, et al. Dental Materials, 2025, 41(2), 159.
43 Babeer A, Liu Y, Ren Z, et al. The Journal of Clinical Investigation, 2024, 135(3), e183576.
44 Xie F, Zhu C, Gong L, et al. Nanoscale, 2023, 15(34), 13971.
45 Alotaibi B, Gaafar S S, Aljuailan R, et al. Microscopy Research and Technique, 2025, 88(6)1654.
46 Feng Y, Sun Q, Liu P, et al. International Journal of Nanomedicine, 2024, 19, 6981.
47 Kong Q, Qi M, Li W, et al. Small, 2023, 19(43), e2302547.
48 Liao W, Ni C, Ge R, et al. ACS Applied Materials Interfaces, 2024, 16(7), 8442.
49 Mei H, Liu H, Sha C, et al. ACS Applied Materials Interfaces, 2024, 16(11), 13573.
50 Nawaz M Z, Alghamdi H A, Zahoor M, et al. Environmental Research, 2024, 241, 117415.
51 Huang Z, Zhou H, Yuan F, et al. ACS Biomaterials Science Engineering, 2024, 10(6), 4059.
52 Guan S, Xu W, Tan J, et al. ACS Nano, 2024, 18(23), 15114.
53 Wen Z, Shi X, Li X, et al. ACS Applied Materials Interfaces, 2023, 15(12), 15235.
54 Yu C, Yu Y, Lu Y, et al. Journal Dental Research, 2024, 103(5), 516.