| INORGANIC MATERIALS AND CERAMIC MATRIX COMPOSITES |
|
|
|
|
|
| In-situ Oxygen-producing Nanoreactor Incorporating Photothermal Effect with Catalase-like Catalysis Potentiates Photodynamic Therapy of Hypoxic Tumor |
| GUO Min1, DANG Yuan1, MA Junping1, XU Huining2,*, ZHOU Yuanzhen1,3, YU Sha1,*
|
1 School of Chemistry and Chemical Engineering, Xi’an University of Architecture and Technology, Xi’an 710055, China
2 Shaanxi Key Laboratory of Environmental Engineering, Xi’an University of Architecture and Technology, Xi’an 710055, China
3 Shaanxi Provincial University Engineering Research Center of Low-Carbon Energy Efficient Utilization, Xi’an 710055, China |
|
|
|
|
Abstract The emerging photodynamic therapy (PDT) is considered to be a promising approach for tumor therapy due to its low systemic toxicity, minor trauma and high therapeutic efficiency. However, the hypoxic environment in tumor tissue severely limits the PDT efficiency. Herein, we developed a hyaluronic acid (HA)-coated nanoreactor (Bi2Se3/ZnPc/Pt@HA, BZPs) based on in situ “oxygen-producing” strategy by integrating the photosensitizer (zinc phthalocyanine, ZnPc) and platinum nanoparticles (Pt NPs) with catalase-like activity on the bismuth-based nanoparticles (Bi2Se3 NPs) with porous structure and photothermal property for synergistically enhancing the PDT efficiency. When the nanoreactor specifically internalized into tumor cells, the HA is degraded by hyaluronidase to expose Bi2Se3/ZnPc/Pt, which can catalyze the decomposition of excess endogenous hydrogen peroxide (H2O2) into oxygen (O2) by using Pt NPs, thus alleviating hypoxia and enhancing the ZnPc-induced PDT efficiency. Meanwhile, the Bi2Se3 can produce hyperpyrexia for photothermal therapy (PTT) and accelerate intracellular ROS production and diffusion, thus significantly improving the PDT efficiency. The cell viability assay and live/dead staining results demonstrate that the nanoreactor has prominent inhibition efficiency for tumor cells. Therefore, the proposed nanoreactor can effectively alleviate hypoxia and enhance the PDT efficiency, which may provide a new avenue for exploring the novel PDT enhancement systems.
|
|
Published:
Online: 2026-04-16
|
|
|
|
|
1 Fan N, Yang M, Liou E D, et al. Materials Reports, 2025, 39(16), 24070042 (in Chinese).
樊娜, 杨梅, 刘德恩, 等. 材料导报, 2025, 39(16), 24070042.
2 Wang J, Dong Y, Ma P, et al. Advanced Materials, 2022, 34(52), 2201051.
3 Song P Y, Deng Y Y, Han H J, et al. Materials Reports, 2020, 34(10), 10166 (in Chinese).
宋鹏宇, 邓永岩, 韩海杰, 等. 材料导报, 2020, 34(10), 10166.
4 Hiller J G, Perry N J, Poulogiannis G, et al. Nature Reviews Clinical Oncology, 2018, 15(4), 205.
5 Tang Z M, Jiang S T, Wang Y D, et al. Materials Reports, 2023, 37(21), 71 (in Chinese).
唐昭敏, 江舒婷, 王郁东, 等. 材料导报, 2023, 37(21), 71.
6 Zhang H, Cui M, Tang D, et al. Advanced Materials, 2024, 36(14), 2310298.
7 Deng K, Yu H, Li J M, et al. Biomaterials, 2021, 275, 120959.
8 Lu Z N, Zhang P, Sheng Y, et al. Materials Reports, 2025, 39(1), 293 (in Chinese).
路正楠, 张鹏, 盛扬, 等. 材料导报, 2025, 39(1), 293.
9 Gan X M, Sun Y W W, et al. Materials Reports, 2024, 38(08), 99 (in Chinese).
甘晓明, 苏玉仙, 应文伟, 等. 材料导报, 2024, 38(08), 99.
10 Dai Phung C, Tran T H, Nguyen H T, et al. Journal of Controlled Release, 2020, 324, 413.
11 Li Y, Du L, Li F, et al. ACS Applied Materials & Interfaces, 2022, 14(13), 14944.
12 Cao H, Wang L, Yang Y, et al. Angewandte Chemie International Edition, 2018, 130(26), 7885.
13 Zhou Z, Zhang B, Wang S, et al. Small, 2018, 14(45), 1801694.
14 Ghaffari-Bohlouli P, Alimoradi H, Petri D F S, et al. Chemical Engineering Journal, 2023, 473, 145072.
15 Zhu X, Wang M, Wang H, et al. Small, 2022, 18(52), 2204951.
16 Zhen W, Liu Y, Wang W, et al. Angewandte Chemie International Edition, 2020, 132(24), 9578.
17 Wei J, Li J, Sun D, et al. Advanced Functional Materials, 2018, 28(17), 1706310.
18 Hao L, Wang L, Ma Y, et al. Coordination Chemistry Reviews, 2024, 499, 215482.
19 Yang X, Liu R, Zhong Z, et al. Chemical Engineering Journal, 2021, 409, 127381.
20 Ye X Y, Mei L, et al. Acta Pharmaceutica Sinica B, 2019, 54(7), 1297 (in Chinese).
叶鑫宇, 梅林, 等. 药学学报, 2019, 54(7), 1297.
21 Jia J, Zhang X, Li Y, et al. Small, 2025, 21(5), 2410535.
22 Han X Y, Li Y F, Lu Y D, et al. China Biotechnology, 2021, 41(11), 48 (in Chinese).
韩雪怡, 李一帆, 陆玥达, 等. 中国生物工程杂志, 2021, 41(11), 48.
23 Liu D, Liang M, Tao Y, et al. Biomaterials, 2024, 309, 122610.
24 Liu Y B, Yu W S, Wang J X, et al. Chinese Journal of Inorganic Che-mistry, 2021, 37(1), 1 (in Chinese).
刘应兵, 于文生, 王进贤, 等. 无机化学学报, 2021, 37(1), 1.
25 Li Z, Liu J, Hu Y, et al. ACS Nano, 2016, 10(10), 9646.
26 He Y, Guo S, Zhang Y, et al. Biomaterials, 2021, 275, 120962.
27 Fan W, Yung B, Huang P, et al. Chemical Reviews, 2017, 117(22), 13566.
28 Feng S, Lu J, Wang K, et al. Chemical Engineering Journal, 2022, 435, 134886.
29 Wen D, Li K, Deng R, et al. Journal of the American Chemical Society, 2023, 145(7), 3952.
30 Ren Q, Yu N, Wang L, et al. Journal of Colloid and Interface Science, 2022, 614, 147. |
|
|
|
渝公网安备50019002502923号 © Editorial Office of Materials Reports.
2026, Vol. 40 
