| INORGANIC MATERIALS AND CERAMIC MATRIX COMPOSITES |
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| Study on Controllable Synthesis and Drug Loading Performance of MnFe2O4 Nanospheres |
| FAN Na1,†, LI Rui1,†, MA Xianglei1, TAN Xiaoyu1, LIU Long1, LI Xuejiao1,2,*
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1 School of Materials Science and Chemical Engineering, Harbin University of Science and Technology, Harbin 150040, China
2 School of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, China |
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Abstract In this work, a series of PEG-modified MnFe2O4 nanomaterials were controllably synthesized by the solvothermal method via changing the ratio of sodium acetate to the reactants and the reaction time. The phase structure, microscopic morphology, magnetic properties and UV-Vision-near-infrared absorption spectra of the samples were analyzed. The self-assembled magnetic PEG-MnFe2O4 nanosphere possessed loosely stacked structures that were conducive to drug loading. Furthermore, the samples with a reaction of 24 h were optimized and the loading and release efficiency of the chemotherapeutic drug doxorubicin (DOX) was investigated in detail at different pH conditions. The results showed that in response to an acidic tumor microenvironment, the samples showed the loading and release rate of DOX (13.28% and 43%, respectively), which was higher than that under neutral conditions. The killing effect of PEG-MnFe2O4@DOX on 4T1 cells was investigated, and the results showed that the MnFe2O4@DOX can effectively kill cancer cells. It is expected to be applied to nanodrug-carrying platforms.
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Published:
Online: 2025-08-28
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2025, Vol. 39 
