| POLYMERS AND POLYMER MATRIX COMPOSITES |
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| Design, Preparation and Performance Evaluation of Porous Wet-Adhesive Hemostasis Sponge |
| GAI Changzhi1,2, FANG Hui3, PAN Zhao1,2,*, DONG Liang1,2,*
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1 School of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China
2 Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China
3 Stomatological College, Anhui Medical University, Anhui 230032, China |
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Abstract Organs such as the liver and kidneys have dense blood vessels and fragile textures, so it is often difficult to control bleeding after trauma, and the tissues are prone to secondary trauma, making surgical hemostasis difficult. Essential characteristics of hemostatic materials designed for non-compressible wounds include the capacity for wet adhesion and fixation without compression, coupled with concurrent physical sealing and facilitation of coagulation. The objective of this study was to engineer a novel hemostatic material, encompassing an oriented porous sponge in conjunction with a polymer cross-linked porous network, culminating in a viscous, double-layered hemostatic sponge produced via lyophilization. This composite material adeptly merges the rapid hemostatic efficacy and coagulative functionality of the oriented chitosan sponge with the enhanced wet-adhesive properties of a porous, viscous matrix. Through microstructural examination, the material’s stratified and porous architecture was authenticated. The double-layered sponge demonstrated superior mechanical robustness and bio-adhesive capabilities. Furthermore, it exhibited commendable biocompatibility, evidenced by a porosity reaching 85% and an impressive blood absorption rate approaching 500%, thereby facilitating expeditious blood uptake and coagulation. In vitro hemostasis simulation experiments have confirmed that the sponge possesses excellent hemostatic effects, showing broad application prospects in the in vivo environment for managing bleeding in delicate organs such as the liver and kidneys. This work also paves new avenues and methods for the development of adhesive hemostatic materials.
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Published: 10 March 2025
Online: 2025-03-18
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2025, Vol. 39 
