功能化有机-无机杂化介孔氧化硅的制备及在智能响应递药系统中的应用

doi:10.11896/cldb.25070013

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Abstract Bridged organic-inorganic hybrid mesoporous silica, also referred to as periodic mesoporous organosilicas (PMOs), is a kind of mesoporous material that has covalently incorporated organic moieties into the silica framework using controlled synthesis techniques. Unlike standard mesoporous silica materials, which are purely inorganic, PMOs use both inorganic and organic properties and advantages having mechanical strength, thermal stability, highly ordered pore architecture, tunable pore size distribution, biocompatibility and low cytotoxicity;these properties indicate that PMOs are prime candidates for delivery of drugs and nanomedicine applications. This review categorizes PMOs on the basis of brid-ging groups, functionalization techniques, describes selected contemporary advances in the synthesis and functionalization of PMOs, and outlines design considerations and current status of stimuli-responsive drug delivery using PMOs that respond to pH, redox, hypoxic, and photothermal (i.e.heat) stimuli as possible tumor therapies. The intention of this review is to serve as a reference guide for rational design of functional PMOs and next generation drug delivery platforms.

Key words： functionalized organic-inorganic hybrid mesoporous silica bridging group intelligent response drug delivery system new drug delivery system

Published: 25 July 2026 Online: 2026-08-12

CLC number:

R94

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	Articles by authors
	ZHANG Yijia
	LYU Jiangwei
	XU Lingfei
	LI Ning
	ZHANG Wenjun

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ZHANG Yijia,LYU Jiangwei,XU Lingfei, et al. Preparation of Functionalized Organic-Inorganic Hybrid Mesoporous Silica and Its Application in Intelligent Response Drug Delivery System[J]. Materials Reports, 2026, 40(14): 25070013-11.

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https://www.mater-rep.com/EN/10.11896/cldb.25070013 OR https://www.mater-rep.com/EN/Y2026/V40/I14/25070013

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