| POLYMERS AND POLYMER MATRIX COMPOSITES |
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| Application of Natural Polysaccharides in Drug Delivery |
| LIU Chenshuang1, TIAN Ye1, SHENG Xianliang2, XIN Siqintana2, ZHANG Yuhui2,*
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1 College of Material Science and Art Design, Inner Mongolia Agricultural University, Hohhot 010018, China
2 College of Science, Inner Mongolia Agricultural University, Hohhot 010018, China |
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Abstract Natural polysaccharides are ideal materials for the preparation of nano-drug carrier systems because of their intrinsic characteristics: good biocompatibility, biodegradability, ease of modification and low toxicity. The incorporation of dynamic covalent bonds such as disulfide bonds, boronate bonds, C-N bonds are a versatile tool for the construction of drug carriers, which can increase drug loading, enhance the biocompatibility, and provide the stimulus-responsive sites. In this regard, many stimuli, such as pH, light and enzyme could be exploited as triggers for drug release, thus making the drug delivery system more intelligent, convenient and controllable. In this paper, the applications of natural polysaccharides in drug delivery systems are reviewed from four aspects: the natural polysaccharides types, dynamic covalent bonds types, stimulus-response types and the clinical indication types of natural polysaccharides. The main challenges and future advances in this field are also detailed.
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Published: 10 October 2024
Online: 2024-10-23
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| Fund:National Natural Science Foundation of China (52263013), the Natural Science Foundation of Inner Mongolia Autonomous Region (2021MS02023), the Program for Improving the Scientific Research Ability of Youth Teachers of Inner Mongolia Agricultural University (BR220140), the Grassland Talents Program of Inner Mongolia Autonomous Region(DC2000000745), and the Program of Higher-level Talents of Inner Mongolia Agricultural University (NDGCC2016-21). |
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2024, Vol. 38 
