| POLYMERS AND POLYMER MATRIX COMPOSITES |
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| Preparation and Anticancer Application of Crosslink-induced Reassembly and Multiple-stimulus Responsive Polymer Micelles |
| TANG Zhaomin*, ZHAO Jianqing, ZHOU Jianren, TANG Wanlan, WEI Jiayuan, HAN Bingkun, LYU Wenxuan
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| School of New Energy and Materials, Southwest Petroleum University, Chengdu 610500, China |
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Abstract This work synthesized a three-block amphiphilic polymers mPEG-P(LL/LL-LA)-PCL-IR820 based on polylysine, in which lysine chain provided reaction sitesfor cross-linking reagent maleic anhydride (LA), and the hydrophobic chain segment polycaprolactone (PCL) provided feasibility for physical encapsulation of anticancer drug doxorubicin (DOX). Subsequently, the photosensitizer IR820 was grafted onto PCL to obtain mPEG-P(LL/LL-LA)-PCL-IR820 via ester bonding. The drug-loaded un-crosslinked micelles (DUCM) were fabricated by solvent evaporation method, and the drug-loaded crosslinked micelles (DCM) were prepared through LA crosslinking induced by the cross-linking inducer dithiothreitol (DTT). Due to the internal crosslinking structure, DCM remained stable after injection and blood circulation. Once entering the tumor cells, the disulfide bond in LA broke down under high concentration of glutathione (GSH) in tumor cells and DOX was rapidly released, which avoided the premature degradation of the uncrosslinked micelles (DUCM) induced by the shear force and protein adsorption and the non-specific distribution of the drug in the body. As a result, the crosslinked micelles showed excellent cytotoxicity to cancer cells combined chemotherapy with photodynamic therapy, which is a promising research in drug delivery system.
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Published: 25 July 2024
Online: 2024-08-12
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| Fund:National Natural Science Foundation of China Youth Fund (51803174) and the Youth Fund of Science and Technology Department of Sichuan Province(2024NSFSC0988). |
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2024, Vol. 38 
