PEGMA刷微图案诱导聚苯乙烯纳米颗粒阵列化

doi:10.11896/cldb.23020080

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Abstract Hydrophilic poly(ethylene glycol) methacrylate (PEGMA) brush micropatterns were prepared on the hydrophobic initiator surface based on the photoinitiated atom transfer radical polymerization (ATRP) reaction. With PEGMA brushes micropatterned substrate acted as a template, the precise assembly of polystyrene (PS) nanoparticles in the hydrophilic region was achieved by utilizing the surface energy difference between hydrophilic and hydrophobic regions, enabling the fabrication of nanoparticle microarrays. X-ray photoelectron spectroscopy (XPS) tests revealed that the covalent immobilization of 3-(Trimethoxysilyl) propyl 2-bromo-2-methylpropanoate (SiBr) initiator on the polydopamine (PDA) surface was achieved. Raman spectroscopy tests indicated the growth of PEGMA brushes on the initiator surface and the assembly of PS nanoparticles on the PEGMA brushes surface. Optical microscopy and scanning electron microscopy (SEM) characterizations showed the selective assembly of PS nanoparticles on the PEGMA brush regions, leading to the successful fabrication of nanoparticle microarrays. Fluorescein thiocyanate-labeled bovine serum protein (FITC-BSA) was applied to detect the protein adsorption behavior of PS nanoparticles, and the results demonstrated the PS nanoparticles could effectively promote the adhesion of BSA protein on the antifouling PEGMA brush region. The presented fabrication technique shows great potential in the fabrication of nanoparticle microarrays with complex structures and provides technical support for the application of nanoparticles in high-throughput bio-microarrays and bioprobes.

Key words： poly (ethylene glycol) methacrylate (PEGMA) brush micropattern hydrophilic-hydrophobic contrast characteristic polystyrene (PS) nanoparticle microarray protein adsorption

Published: 25 July 2024 Online: 2024-08-12

CLC number:

TB303

Fund:National Natural Science Foundation of China (52103262).

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	Articles by authors
	GAO Hao
	WEI Zhonghua
	DENG Jia
	CHEN Tao
	ZHAO Haili

Cite this article:

GAO Hao,WEI Zhonghua,DENG Jia, et al. The Fabrication of Polystyrene Nanoparticle Microarrays Through the Micropatterned PEGMA Brush Induced Assembly[J]. Materials Reports, 2024, 38(14): 23020080-7.

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http://www.mater-rep.com/EN/10.11896/cldb.23020080 OR http://www.mater-rep.com/EN/Y2024/V38/I14/23020080

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