INORGANIC MATERIALS AND CERAMIC MATRIX COMPOSITES |
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Research Progress of SARS-CoV-2 Detection Based on Microfluidic Chip |
CHEN Runhua1, DAI Yongqi1, ZHANG Jianye2, LI Fangde2, LU Yanjun1,*
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1 College of Mechatronics and Control Engineering, Shenzhen University, Shenzhen 518060, Guangdong, China 2 Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China |
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Abstract Regarded as an integrated, high-through put and low-cost biological analysis and detection tool, microfluidic chip has attracted much attention in the detection of SARS-CoV-2 in recent years. Firstly, the latest progress of microfluidic chip and its systems in SARS-CoV-2 testing are reviewed, and we also describe and compare the materials and preparation process of microfluidic chip. Then, we focus on detection technologies based on microfluidic chip such as nucleic acid molecular tests, serological tests and point of care tests (POCT), which provides reference value for innovative design of detection method and chip preparation. The combination of biological detection technology and microfluidics equipment could effectively realize efficient, sensitive and accurate detection of SARS-CoV-2. Virus testing methods based on microfluidic chip would be an effective alternative to the traditional virus testing method, which presents the characteristics of diversification and integration. Lastly, the applicability and current challenges of various detection technologies are also discussed, which would help scholars to carry out more extensive and in-depth biomedical analysis and detection research and deepen their understanding of the development prospects of advanced detection technologies and microfluidic technologies.
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Published: 25 June 2024
Online: 2024-07-17
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Fund:National Natural Science Foundation of China (51805334) and the Science and Technology Program of Guangdong Province (2022A0505050080). |
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