载中药聚乳酸多孔纳米纤维医用敷料

doi:10.11896/cldb.22080169

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Abstract In order to construct a medical dressing with the absorbability by human body, antibacterial and anti-inflammatory property, thin and soft characteristic for wound healing, polylactic acid (PLA) porous nanofibers dressings loaded with traditional Chinese medicines of radix isatidis (RI), bupleurum chinense (BC) and green tea polyphenols (GTP) were prepared by electrospinning technique, which used the mixture of chlo-roform and acetone as solvent system. By means of scanning electron microscope, infrared spectrometer, X-ray diffractometer (XRD) and contact angle tester, the microstructure, wettability, water retention and liquid absorption, antibacterial and in vitro degradation of the dressing were analyzed. The results show that the nanofibers of dressing loaded Chinese medicine prepared by chloroform and acetone two solvent system had porous characteristics, and the fiber diameter was about 747—1 550 nm. There was no negative modification reaction between Chinese medicine ingredients and polylactic acid. The antibacterial rates of the dressings loaded with radix isatidis, bupleuri chinense and green tea polyphenols against staphylococcus aureus were 79.2%, 82.5% and 75.7% respectively when the loading drug content was 3%, and the antibacterial rates against Escherichia coli were 79.1%, 80.2% and 73.9% respectively. At the same time, compared with pure polylactic acid dressings, the dres-sings loaded drug have better air permeability and in vitro degradation performance, and their water retention and liquid absorption properties are improved by more than 20%, which is suitable for use as wound dressings.

Key words： porous polylactic acid nanofiber radix isatidis green tea polyphenols bupleurum chinense dressing antibacterial property

Published: 25 May 2024 Online: 2024-05-28

CLC number:

TS174.8

Fund:National Key R & D Program of China (2017YFB0309100).

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	Articles by authors
	LI Liang
	LIU Shuping
	PEI Feifei
	YANG Leifeng
	LIU Rangtong

Cite this article:

LI Liang,LIU Shuping,PEI Feifei, et al. Medical Dressing Prepared from Polylactic Acid Porous Nanofiber Loaded Chinese Drugs[J]. Materials Reports, 2024, 38(10): 22080169-7.

URL:

http://www.mater-rep.com/EN/10.11896/cldb.22080169 OR http://www.mater-rep.com/EN/Y2024/V38/I10/22080169

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