| INORGANIC MATERIALS AND CERAMIC MATRIX COMPOSITES |
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| Copper Peroxide Coated Mesoporous Silica Nanoparticles for Tumor Treatment by the Combination of Chemodynamic Therapy and Chemotherapy |
| TANG Zhaomin*, JIANG Shuting, WANG Yudong, TANG Wanlan, SHU Juan, ZHANG Jiyang, HE Haoyang, CHEN Kongjun
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| School of New Energy and Materials, Southwest Petroleum University, Chengdu 610500, China |
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Abstract Chemodynamic therapy is a novel method, which uses a Fenton catalyst to catalyze intracellular hydrogen peroxide into hydroxyl radicals to kill cancer cells. However, the low level of intracellular H2O2 in tumor cells and the limitations of monotherapy limit the effective treatment performance. Here we report a kind of copper peroxide-loaded mesoporous silica nanoparticle (MSN) in which doxorubicin (DOX) was loaded into the pores, then CuO2 catalyst was coated on the surface of MSN to prevent the premature of drug release. Under the stimulus of the tumor microenvironment (TME), CuO2 was decomposed to produce hydrogen peroxide(H2O2) and the Fenton-like ion Cu2+. Then, Cu2+ consumed the intracellular glutathione (GSH) to produce Cu+, which catalyzed H2O2 to produce the highly cytotoxic ·OH. Meanwhile, the successful delivery of DOX from MSN realizes the integration of chemodynamic therapy and chemotherapy. In addition, the experiments in vitro showed that this Fenton catalyst DOX@MSN@CuO2 exhibits good cytocompatibility and excellent cytotoxicity, which provides a new strategy for tumor treatment.
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Published: 10 November 2023
Online: 2023-11-10
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| Fund:National Natural Science Foundation of China Youth Fund (51803174), the 21st Extracurricular Open Experiment Key Project of Southwest Petroleum University (2021KSZ05004). |
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2023, Vol. 37 
