Fe<sub>3</sub>O<sub>4</sub>磁性纳米药物用于克服肿瘤多药耐药性的研究

doi:10.11896/cldb.22010219

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Abstract Multidrug resistance (MDR) of tumor is a major obstacle to the treatment of cancer. Therefore, it is necessary to develop a drug delivery system that can overcome MDR. In this work, a magnetic nanomedicine Fe₃O₄@PDA-TPP/S₂-PEG-hyd-DOX (Fe₃O₄-ATSPD) was designed, and chemotherapy combined with photothermal therapy (PTT) was used to overcome MDR of tumor. This nanomedicine shows high stability in blood circulation, and can be accumulated at the tumor site through the magnetic targeting enhanced high permeability and retention effect (EPR). When intracellular uptake by tumor cells, DOX is released from Fe₃O₄-ATSPD under acidic condition. Meanwhile, the disulfide bond is broken with the high concentration of glutathione (GSH), exposing the targeting group of triphenylphosphine (TPP) modified photothermal agent Fe₃O₄-AT. After near-infrared light (NIR) irradiation, the photothermal effect is generated quickly, leading to the mitochondrial dysfunction. The experimental results in vitro and in vivo show that chemotherapy combined with PTT has the best antitumor effect and safety.

Key words： multidrug resistance mitochondrial-targeting near infrared irradiation cancer therapy

Published: 10 August 2023 Online: 2023-08-07

CLC number:

R730.53

Fund:National Natural Science Foundation of China (51803174).

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	TANG Zhaomin
	TIAN Weijun

Cite this article:

TANG Zhaomin,TIAN Weijun. Study on Fe₃O₄-based Magnetic Nanomedicine for Overcoming Multidrug Resistance in Cancer[J]. Materials Reports, 2023, 37(15): 22010219-7.

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http://www.mater-rep.com/EN/10.11896/cldb.22010219 OR http://www.mater-rep.com/EN/Y2023/V37/I15/22010219

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