类过氧化氢酶催化和光热效应协同诱导的原位产氧型纳米反应器用于促进乏氧肿瘤光动力治疗

doi:10.11896/cldb.25030253

材料导报

2026, Vol. 40

Issue (7): 25030253-8 https://doi.org/10.11896/cldb.25030253

无机非金属及其复合材料

类过氧化氢酶催化和光热效应协同诱导的原位产氧型纳米反应器用于促进乏氧肿瘤光动力治疗

郭敏¹, 党媛¹, 马军平¹, 徐会宁^2,*, 周元臻^1,3, 于莎^1,*

1 西安建筑科技大学化学与化工学院,西安 710055
2 西安建筑科技大学环境工程陕西省重点实验室,西安 710055
3 陕西省高校低碳能源高效利用工程技术研究中心,西安 710055

In-situ Oxygen-producing Nanoreactor Incorporating Photothermal Effect with Catalase-like Catalysis Potentiates Photodynamic Therapy of Hypoxic Tumor

GUO Min¹, DANG Yuan¹, MA Junping¹, XU Huining^2,*, ZHOU Yuanzhen^1,3, YU Sha^1,*

1 School of Chemistry and Chemical Engineering, Xi’an University of Architecture and Technology, Xi’an 710055, China
2 Shaanxi Key Laboratory of Environmental Engineering, Xi’an University of Architecture and Technology, Xi’an 710055, China
3 Shaanxi Provincial University Engineering Research Center of Low-Carbon Energy Efficient Utilization, Xi’an 710055, China

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摘要光动力治疗(PDT)具有毒性低、创伤小以及治疗效率高等优点,是一种前景广阔的癌症治疗方法。然而,肿瘤组织的缺氧环境严重限制了PDT的治疗效率。为此,本工作将光敏剂(酞菁锌,ZnPc)和具有类过氧化氢酶活性的铂纳米粒子(Pt NPs)整合在具有多孔结构和光热性质的铋基纳米载体(Bi₂Se₃)上,并采用透明质酸(HA)进行封装,开发了一种原位产氧型纳米反应器(Bi₂Se₃/ZnPc/Pt@HA,BZPs),以协同提高PDT效率。当纳米反应器特异性地内化至肿瘤细胞内部时,透明质酸酶会降解HA,使Bi₂Se₃/ZnPc/Pt暴露出来,其中的Pt NPs可将内源性过氧化氢(H₂O₂)催化分解成氧气(O₂),改善肿瘤乏氧环境,以提高PDT治疗效率。同时,Bi₂Se₃的高光热转换效率,可使肿瘤细胞内局部温度升高,加速细胞内活性氧物种(ROS)的产生和扩散,从而显著提高PDT治疗效率。细胞毒性测试和活/死染色结果表明,该纳米反应器对肿瘤细胞具有显著的抑制作用。因此,所提出的原位产氧型纳米反应器能有效缓解肿瘤乏氧状况,为克服肿瘤微环境限制和提高PDT疗效提供了一种新策略。

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关键词: 纳米反应器类过氧化氢酶原位产氧光动力疗法乏氧肿瘤

Abstract: The emerging photodynamic therapy (PDT) is considered to be a promising approach for tumor therapy due to its low systemic toxicity, minor trauma and high therapeutic efficiency. However, the hypoxic environment in tumor tissue severely limits the PDT efficiency. Herein, we developed a hyaluronic acid (HA)-coated nanoreactor (Bi₂Se₃/ZnPc/Pt@HA, BZPs) based on in situ “oxygen-producing” strategy by integrating the photosensitizer (zinc phthalocyanine, ZnPc) and platinum nanoparticles (Pt NPs) with catalase-like activity on the bismuth-based nanoparticles (Bi₂Se₃ NPs) with porous structure and photothermal property for synergistically enhancing the PDT efficiency. When the nanoreactor specifically internalized into tumor cells, the HA is degraded by hyaluronidase to expose Bi₂Se₃/ZnPc/Pt, which can catalyze the decomposition of excess endogenous hydrogen peroxide (H₂O₂) into oxygen (O₂) by using Pt NPs, thus alleviating hypoxia and enhancing the ZnPc-induced PDT efficiency. Meanwhile, the Bi₂Se₃ can produce hyperpyrexia for photothermal therapy (PTT) and accelerate intracellular ROS production and diffusion, thus significantly improving the PDT efficiency. The cell viability assay and live/dead staining results demonstrate that the nanoreactor has prominent inhibition efficiency for tumor cells. Therefore, the proposed nanoreactor can effectively alleviate hypoxia and enhance the PDT efficiency, which may provide a new avenue for exploring the novel PDT enhancement systems.

Key words: nanoreactor catalase-like enzyme in-situ oxygen-production photodynamic therapy hypoxic tumor

发布日期: 2026-04-16

ZTFLH:

R730.53

基金资助: 国家自然科学基金(22274125;22104118);陕西省科学技术协会青年人才托举计划(20240619)

通讯作者: *徐会宁,硕士,西安建筑科技大学环境与市政工程学院工程师,目前从事仪器分析与管理工作。63212109@qq.com
于莎,博士,西安建筑科技大学化学与化工学院副教授、硕士研究生导师。目前主要研究光、电功能纳米材料的制备及其在疾病诊断和治疗中的应用。shayu@xauat.edu.cn

作者简介: 郭敏,西安建筑科技大学化学与化工学院硕士研究生,主要研究铋基纳米复合材料的合成及其在癌症治方面的应用。

引用本文:

郭敏, 党媛, 马军平, 徐会宁, 周元臻, 于莎. 类过氧化氢酶催化和光热效应协同诱导的原位产氧型纳米反应器用于促进乏氧肿瘤光动力治疗[J]. 材料导报, 2026, 40(7): 25030253-8.
GUO Min, DANG Yuan, MA Junping, XU Huining, ZHOU Yuanzhen, YU Sha. In-situ Oxygen-producing Nanoreactor Incorporating Photothermal Effect with Catalase-like Catalysis Potentiates Photodynamic Therapy of Hypoxic Tumor. Materials Reports, 2026, 40(7): 25030253-8.

链接本文:

https://www.mater-rep.com/CN/10.11896/cldb.25030253 或 https://www.mater-rep.com/CN/Y2026/V40/I7/25030253

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