Abstract: The final sterilized medical device packaging was closely related to the safety of medical devices in healthcare institutions, and more importantly, to the life and health of patients. Breathable materials have become the predominant materials for medical sterilization packaging because of their superior performance in effectively balancing gas exchange and microbial barrier during the sterilization process. In this review, we systematically summarize the recent advances of the sterilization medical device packaging, and categorize material selection criteria for various packaging forms. Additionally, we focus on the application of polymer-based and paper-based breathable materials in packaging, and present re-levant spinning and papermaking processes. Factors affecting fiber filament properties are also thoroughly analyzed. Finally, we discuss in detail the regulation of nonwoven membrane material properties, including optimizing breathability, mechanical strength, microbial barrier efficacy, and water resistance through strategies such as process adjustment and surface modification. This review may provide technical references for promoting the development of medical packaging materials.
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