贻贝仿生聚酚胺涂层固定REDV短肽促内皮化探究

doi:10.11896/cldb.23020001

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Abstract With the development of drug-eluting stents (DES), the rate restenosis of stents was reduced. However, the introduced drugs inevitably caused damage to the endothelial layer, thus affecting the integrity and functionality of the endothelial barrier at the lesion site. A structurally intact and functional vascular endothelial cell layer is essential for maintaining vascular tissue homeostasis as well as coagulation system homeostasis. The pre-treatment of stents with a pro-endothelialization coating that combines excellent hemocompatibility is an effective strategy to improve the complications of cardiovascular implantation devices such as stents. In this work, the oxidant sodium periodate was chosen to accelerate the self-polymerization of dopamine, which led to the rapid formation of poly(phenol-amine) coating PDA on the surface of the stent material. The preparation method was simple and time-saving. Subsequently, the functional short peptide REDV was immobilized by Michael addition reaction to construct a re-endothelialized P-REDV coating. REDV showed high grafting efficiency and large grafting density (9.84 ng/cm²). This coating also showed selective promotion of endothelial cell adhesion when tested in vitro assays, as well as excellent hemocompatibility. This provided a new strategy to address the problem of delayed endothelialization after drug-eluting stents and cardiovascular implantation devices.

Key words： phenol-amine chemistry click grafting endothelial promotion vascular stents REDV

Published: 10 July 2024 Online: 2024-08-01

CLC number:

Q81

Fund:Sichuan Province International Science and Technology Innovation Cooperation Project (2021YFH0056).

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	Articles by authors
	WEI Jiajia
	MENG Haotian
	LI Pengcheng
	WANG Wenxuan
	LI Mengru
	TU Qiufen

Cite this article:

WEI Jiajia,MENG Haotian,LI Pengcheng, et al. Exploration of Mussel Biomimetic Poly (Phenol-Amine) Coating to Immobilize REDV Peptide for Endothelial Promotion[J]. Materials Reports, 2024, 38(13): 23020001-7.

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http://www.mater-rep.com/EN/10.11896/cldb.23020001 OR http://www.mater-rep.com/EN/Y2024/V38/I13/23020001

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