| METALS AND METAL MATRIX COMPOSITES |
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| Progress on the Research of In-vivo Degradation Behavior and Surface Modification of Biomedical Mg Alloys |
| ZHENG Yang1,2,*, ZHANG Xuan2, LU Jia2, HE Donglei3, SU Zhenyu2, NIU Wei2, YU Zhenyang2, SUN Ronglu2, LI Yan3,4,*
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1 School of Aeronautics and Astronautics, Tiangong University, Tianjin 300387, China
2 School of Mechanical Engineering, Tiangong University, Tianjin 300387, China
3 School of Materials Science and Engineering, Beihang University, Beijing 100191, China
4 Beihang Hangzhou Innovation Institute Yuhang, Hangzhou 310023, China |
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Abstract Biomedical Mg alloys are ideal temporary implants in non-important bearing sites in human body due to their good biocompatibility, excellent comprehensive mechanical properties and unique biodegradability. However, fast degradation of Mg alloys in the physiological environment severely restricts their clinical applications. The key solution to solve the problem is exploring more suitable implantation sites for Mg alloys and synchronizing their degradation rate with tissue healing process via appropriate surface modification methods. In recent years, researchers at home and abroad systematically studied their degradation mechanism in different in-vivo environments. They also conducted various surface mo-dification methods to regulate their corrosion behavior by preparing coatings with suitable composition and microstructure. First of all, this paper analyzes the effects of physiological environment (including kinds, compositions, concentrations, flow conditions of the corrosive media) on the degradation behavior of Mg alloys. Then, this paper summarizes the degradation behavior of Mg alloys in different implantation sites of orthopedics, cardiovascular, gastroenterology, urology departments. Following that, this paper reviews the research progress in degradation behavior regulation of Mg alloys using various kinds of coatings such as metallic coatings, inorganic non-metallic coatings, organic polymer coatings, biological functional coatings and composite coatings. Finally, this paper puts forward some development directions of bio-functional coatings based on different specific implantation sites, which could provide reference for promoting the clinical applications of Mg alloys.
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Published: 10 October 2023
Online: 2023-09-28
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| Fund:Tianjin Municipal Natural Science Foundation (19JCQNJC02800) and National Natural Science Foundation of China (51971014). |
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2023, Vol. 37 
