亚铁离子荧光探针研究进展

doi:10.11896/cldb.21030055

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Abstract Ferrous ion (Fe²⁺), as the most abundant iron element in living organisms, is closely related to the metabolism in live organisms. The abnormal Fe²⁺ levels involve in the occurrence and development of various diseases such as anemia, cancer and cardiovascular diseases. Therefore, the monitoring of Fe²⁺ fluctuation in living systems is of great significance to evaluate human health. Among of the several Fe²⁺ detection approaches, fluorescence method is widely employed due to its easy operation and on-site capability in vivo/in vitro.
Design and screening of fluorescent probes play key roles in fluorescence detection. However, a typical difficulty of the traditional fluorescent probes is how to avoid the interference from other metal ions (such as calcium, magnesium and potassium). Thus, the designs of fluorescent probes with excellent specificity, photostability, sensitivity and biocompatibility have been devoted by scientists.
According the materials of probes, they are always classified into organic molecular probes and nano probes. In parallel, the probes included three reaction mechanisms for detecting Fe²⁺: (1) reduction of NO groups;(2) chelation with Fe²⁺;(3) specifical reaction with Fe²⁺ (for example: Fenton reaction, selective cleavage of amide or hydroxylamine bonds, etc.).
Here, we have summarized the research progress of Fe²⁺ fluorescent probes in the past decade, including synthesis methods, detection mechanism and bio-application progress. We envision the further optimization of the luminescence property, detection limit and specificity of fluorescent probe.

Key words： ferrous ion fluorescent probe identification bioimaging

Published: Online: 2023-02-08

CLC number:

O657.3

Fund:National Natural Science Foundation of China (21705001, 21775001).

Corresponding Authors: zrl@ahu.edu.cn

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	LI Jiajia
	ZHANG Ruilong
	ZHANG Zhongping

Cite this article:

LI Jiajia,ZHANG Ruilong,ZHANG Zhongping. Research Progress of Ferrous Ion Fluorescent Probe[J]. Materials Reports, 2023, 37(2): 21030055-8.

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http://www.mater-rep.com/EN/10.11896/cldb.21030055 OR http://www.mater-rep.com/EN/Y2023/V37/I2/21030055

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