可降解医用金属功能化表面改性研究进展

doi:10.11896/cldb.20030011

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Abstract In recent years, biodegradable metals, including magnesium-, iron- and zinc-based alloys, have become attractive research topics due to their excellent biodegradation performance and biocompatibility. Biodegradable metals can be degraded and absorbed by the human body during/after fulfilling the mission to assist with tissue healing and can avoid the requirement for a secondary removal surgery.
However, previous studies have shown that there are still some deficiencies in the practical clinical application of the three biodegradable metals. For example, the in vivo degradation rate of magnesium and magnesium-based alloy is too fast;on the other hand,the in vivo degradation rate of iron and iron-based alloy is too slow and the low mechanical properties of zinc and zinc-based alloys limit their application. In addition, as one kind of biomedical material, it is necessary to be afforded properties such as biocompatibility, wear resistance, corrosion resistance, appropriate mechanical properties, osseointegration, high hardness, ductility, and antibacterial activity according to different clinical applications. In order to improve the properties of biodegradable metals, approaches such as alloying, subsequent treatment and surface modification can be utilized. Nevertheless, it is difficult to control the local corrosion of implants and ensure the mechanical integrity of implants by adding alloying elements. Surface modification is the simplest and most effective method to improve the properties of biodegradable metals with low cost. In view of this aspect, functional surface modification technology of biodegradable metals has been introduced. Functional surface modification technology can not only control the corrosion behavior of biodegradable metals, but also improve their biocompatibility, antibacterial activity, anticoagulant activity, anticoagulant property and osteogenic properties according to different clinical requirements.
Currently, various surface modification techniques such as conversion coating, deposition coating, composite coating, etc. have been proved to be effective in improving the properties of biodegradable metals. Magnesium and magnesium-based alloys are the most widely studied biodegradable metals, and various modification technologies have been shown to significantly reduce the corrosion rate of magnesium alloys. The surface modification technology for iron and iron-based alloys mainly focuses on pure iron and Fe-Mn alloys, but the current surface modification technology is difficult to improve the biodegradation behavior. Zinc and its alloys are a new generation of biodegradable metals. The existing surface modification technology is mainly to enhance their biocompatibility and antibacterial properties.
In this review, we summarize the research on functional surface modification of biodegradable metals and the future research trend has been prospected as well.

Key words： biodegradable metals surface modification biocompatibility clinical applications

Published: 19 January 2021

CLC number:

TG146.1

Fund:This work was financially supported by the National Natural Science Foundation of China (31700819), the Young Elite Scientists Sponsorship Program by CAST (2018QNRC001), and the Fundamental Research Funds for the Central Universities (FRF-GF-19-007B).

About author:: Huafang Li received her Ph.D. degree in advanced materials and mechanics in Peking University in 2014. She then joined the Department of Orthopaedics and Traumatology, Faculty of Medicine in Chinese University of Hong Kong as a postdoc research fellow from 2014 to 2018. In 2018, Dr. Li joined School of Materials Science and Engineering, University of Science and Technology Beijing as an associate professor. She has joined the 4th Young Elite Scientists Sponsorship Program in 2018. Her research interests include design and development metallic biomaterials and implants, biodegradable metals and surface modification of biomaterials. She has authored/co-authored over 50 peer-reviewed journal papers including Nature Medicine, Biomaterials, Acta Biomaterialia, etc.

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	LI Huafang
	ZHENG Yixing
	WANG Luning

Cite this article:

LI Huafang,ZHENG Yixing,WANG Luning. Research Progress on Functional Surface Modification of Biodegradable Metals[J]. Materials Reports, 2021, 35(1): 1168-1176.

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http://www.mater-rep.com/EN/10.11896/cldb.20030011 OR http://www.mater-rep.com/EN/Y2021/V35/I1/1168

1 Asri R I M, Harun W S W, Samykano M, et al. Materials Science and Engineering: C,2017,77,1261.
2 Zheng Y F, Gu X N, Witte F. Materials Science and Engineering: R: Reports,2014,77,1.
3 Zheng Y F, Wu Y H. Acta Metallurgica Sinica,2017,53(3),257(in Chinese).
郑玉峰,吴远浩.金属学报,2017,53(3),257.
4 Li N, Zheng Y. Journal of Materials Science & Technology,2013,29(6),489.
5 Liu L, Yang Q, Huang L, et al. Applied Surface Science,2019,484,511.
6 Wang L N, Meng Y, Liu L J, et al. Acta Metallurgica Sinica,2017,53(10),1317.
王鲁宁,孟瑶,刘丽君,等.金属学报,2017,53(10),1317.
7 Su Y, Wang K, Gao J, et al. Acta Biomaterialia,2019,98,174.
8 Li H, Yang H, Zheng Y, et al. Materials & Design,2015,83,95.
9 Li H F, Shi Z Z, Wang L N. Journal of Materials Science & Technology,2020,46,136.
10 Chen H, Zhang E, Yang K. Materials Science and Engineering: C,2014,34,201.
11 Li H, Zheng Y, Qin L. Progress in Natural Science: Materials International,2014,24(5), 414.
12 Zou Y H, Wang J, Cui L Y, et al. Acta Biomaterialia,2019,98,196.
13 Wu H, Zhang C, Lou T, et al. Acta Biomaterialia,2019,98,152.
14 Yin Z Z, Qi W C, Zeng R C, et al. Journal of Magnesium and Alloys,2020,8(1),42.
15 Yan T, Tan L, Zhang B, et al. Journal of Materials Science & Technology,2014,30(7),666.
16 Saranya K, Kalaiyarasan M, Rajendran N. Surface and Coatings Techno-logy,2019,378,124902.
17 Prabhu D B, Gopalakrishnan P, Ravi K R. Journal of Alloys and Compounds,2020,812,152146.
18 Zhang X P, Zhao Z P, Wu F M, et al. Journal of Materials Science,2007,42(20), 8523.
19 Gu X N, Li N, Zhou W R, et al. Acta Biomaterialia,2011,7(4),1880.
20 Chen J, Zhang Y, Ibrahim M, et al. Colloids and Surfaces B: Bioin-terfaces,2019,179,77.
21 Aktug S L, Durdu S, Aktas S, et al. Surface and Coatings Technology,2019,375,46.
22 Chen X B, Nisbet D R, Li R W, et al. Acta Biomaterialia,2014,10(3),1463.
23 Pan Y K, Chen C Z, Wang D G, et al. Colloids and Surfaces. B, Bioin-terfaces,2013,109,1.
24 Cui L Y, Wei G B, Han Z Z, et al. Journal of Materials Science & Technology,2019,35(3),254.
25 Song Y, Zhang S, Li J, et al. Acta Biomaterialia,2010,6(5),1736.
26 Levy G, Aghion E. Acta Biomaterialia,2013,9(10),8624.
27 Catt K, Li H, Cui X T. Acta Biomaterialia,2017,48,530.
28 Xiong P, Yan J, Wang P, et al. Acta Biomaterialia,2019,98,160.
29 Xiong P, Jia Z, Zhou W, et al. Acta Biomaterialia,2019,92,336.
30 Wang Q, Tan L, Yang K. Journal of Materials Science & Technology,2015,31(8),845.
31 Li L Y, Cui L Y, Zeng R C, et al. Acta Biomaterialia,2018,79,23.
32 Jothi V, Adesina A Y, Kumar A M, et al. Surface and Coatings Techno-logy,2020,381,125139.
33 Li J A, Chen L, Zhang X Q, et al. Materials Science and Engineering: C,2020,109,110607.
34 Cui L Y, Qin P H, Huang X L, et al. Surface and Coatings Technology,2017,324,560.
35 Waksman R O N, Pakala R, Baffour R, et al. Journal of Interventional Cardiology,2008,21(1),15.
36 Zhu S F, Huang N, Xu L, et al. Surface and Coatings Technology,2009,203(10),1523.
37 Zhu S F, Huang N, Shu H, et al. Applied Surface Science,2009,256(1),99.
38 Cheng J, Huang T, Zheng Y F. Materials Science and Engineering: C,2015,48,679.
39 Qi Y, Li X, He Y, et al. ACS Applied Materials & Interfaces,2019,11(1),202.
40 Oriňaková R, Gorejová R, Orságová Králová Z, et al. Applied Surface Science,2020,505,144634.
41 Donik , Kocijan A, Paulin I, et al. Applied Surface Science,2018,453,383.
42 Wen Z, Zhang L, Chen C, et al. Materials Science and Engineering: C,2013,33(3),1022.
43 Mohd Daud N, Sing N B, Yusop A H, et al. Journal of Orthopaedic Translation,2014,2(4),177.
44 Su Y, Champagne S, Trenggono A, et al. Materials & Design,2018,148,124.
45 Drevet R, Zhukova Y, Kadirov P, et al. Metallurgical and Materials Transactions A,2018,49(12),6553.
46 Ray S, Thormann U, Eichelroth M, et al. Biomaterials,2018,157,1.
47 Yang C, Huan Z, Wang X, et al. ACS Biomaterials Science & Enginee-ring,2018,4(2),608.
48 Zhou J, Yang Y, Detsch R, et al. Applied Surface Science,2019,492,669.
49 Zhou C, Li H F, Yin Y X, et al. Acta Biomaterialia,2019,97,657.
50 Li H, Xie X, Zheng Y, et al. Scientific Reports,2015,5,10719.
51 Yuan W, Li B, Chen D, et al.ACS Biomaterials Science & Engineering,2019,5(2),487.
52 Yuan W, Xia D, Zheng Y, et al. Acta Biomaterialia,2020,105,290.