三种金属有机框架对苯达莫司汀的载药研究

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Abstract Three metal organic frameworks (MOFs), UiO-66, UiO-66-NH₂ and UiO-66-COOH, were synthesized with different organic ligands centered on metal Zr ions,then the bendamustine was loaded into them by impregnation method, and their loading capacities were investigated in this study. Infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction method and scanning electron microscope were used to characterize the MOFs before and after drug loading. The results showed that the three MOFs were successfully loaded with bendamustine and the crystal structures of them were not changed before and after drug loading. The thermal stability was strong and the drug-loading capacity of UiO-66-COOH was better than that of UiO-66-NH₂ and UiO-66. According to the specific functional group of the drug, the corresponding MOFs with high matching degree can be synthesized to increase the drug loading.

Key words： metal organic framework UiO-66 UiO-66-NH₂ UiO-66-COOH bendamustine

Published: 01 July 2020

CLC number:

R94

Fund:This work was financially supported by Natural Science Foundation of Liaoning Province (Material Joint Fund) (2018010051-301).

About author:: Sengqun Zhao received his B.S. degree in Shenyang Pharmaceutical University in 2017. He is currently pursuing his master's degree at the College of Pharmacy, Liaoning University under the supervision of associate prof. Li Li. His research has focused on new drug form ; Li Li received her B.E., M.S., and Ph.D. degrees in pharmaceutics from Shenyang Pharmaceutical University in 2000, 2005, and 2010 respectively. She is also a visiting scholar in the University of Michigan Ann Arbor for one year in 2013. The focus of her research is on the nano drug delivery system. To date, she has published 37 papers in peer-reviewed pharmaceutical journals.

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	ZHAO Sengqun
	LI Xurui
	HAN Shasha
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Cite this article:

ZHAO Sengqun,LI Xurui,HAN Shasha, et al. Study on Drug Loading of Bendamustine with Three Metal Organic Frameworks[J]. Materials Reports, 2020, 34(Z1): 523-526.

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http://www.mater-rep.com/EN/ OR http://www.mater-rep.com/EN/Y2020/V34/IZ1/523

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