柔性电子在糖尿病诊断、治疗及护理中的应用综述

doi:10.11896/cldb.19100178

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Abstract Diabetes is a common chronic metabolic disease characterized by high glucose concentrations in the blood, adversely affecting the health and diminishing the qualities of life of patients. In addition, diabetes can also cause a series of complications, rendering it difficult to restore the health of patients with medication alone. The development of these complications may lead to disability or even death. With the rise of artificial intelligence and Internet of Things, flexible electronics has been gradually employed for the treatment of diabetes in recent years due to its unique advantages such as being lightweight, stretchable, or bendable.
To treat and control the development of diabetes, patients need to regularly detect glucose content in the blood and take medication over a long term period. Traditional methods of diagnosing diabetes are unable to detect the glucose level in the blood continuously and in real time, causing trauma and delaying the best treatment time for patients. Due to inadequate nursing mechanism and backward nursing equipment, the conditions of patients may worsen rapidly.
Flexible electronics are integrated into wearable flexible electronic devices through integration with sensing technologies. These equipment can be directly worn on the body, and are able to detect the glucose level in the body continuously and in real time through non-invasive or minimally invasive detection methods. By integrating drug delivery devices and wireless communication equipment, the setup can intelligently control drug dosage, render drug treatment, as well as carry out real-time health monitoring and exercise assistance for diabetic patients. Therefore, wearable flexible electronic devices provide new ways for diagnosis, treatment, and nursing care of diabetes, and has become the most ideal platform for individualized management of diabetes.
This paper reviews the applications of flexible wearable devices in the diagnosis, treatment, and nursing care for diabetes in recent years. The challenges faced in the development of flexible wearable devices are also discussed. Progress in the area of flexible wearable devices may potentially alleviate problems faced by diabetic patients, thereby improving their quality of life.

Key words： flexible electronics wearable devices diabetes glucose detection health care biosensing

Published: 15 January 2020

CLC number:

TN04

Fund:This research was supported by National Key R&D Program of China (2018YFC1105402), the National Natural Science Foundation of China (21875189), the Innovative Talents Promotion Project of Shannxi Province of China (2019KJXX-064), the Natural Science Basic Research Plan in Shaanxi Province of China (2019JQ-157), and the Fundamental Research Funds for the Central Universities (G2018KY0305,G2018KY0307).

About author:: Jiang Song received his B.E. degree in Optoelectronic Information Science and Engineering from China University of Petroleum in June 2019. He is currently pursuing his Master's degree in the Institute of Flexible Electronics, Northwestern Polytechnical University. His research focuses on flexible bioelectronic devices.
Tengjiao Wang is an associate professor in the Institute of Flexible Electronics (Xi’an Institute of Biomedical Materials and Engineering), Northwestern Polytechnical University (NPU). He received his B.S. in Polymer Science and Engineering from Beijing University of Chemical Technology in 2010 and Ph. D. in Polymer Material and Science from Osaka University in 2016. After 2 years of postdoctoral research at The University of Arkansas, he joined the Institute of Flexible Electronics, NPU in 2018. Dr. Wang’s experience is involved in the fields of polymer chemistry, nanomedicine and organic chemistry, and his research aims at developing polymeric materials for biomedical applications. He has published 13 SCI papers in the field of anti-bacteria, anti-cancer and wound-healing research in academic journals including Polymer Chemistry, Langmuir, Macromolecular Bioscience et al.
Wei Huang received his B.S., M.S., and Ph.D. degrees in Chemistry from Peking University in 1983, 1988, and 1992, respectively. In 2001, he became a chair professor at Fudan University, where he founded the Institute of Advanced Materials (IAM). In 2006, he was appointed as the Deputy President of Nanjing University of Posts and Telecommunications. He was elected as the Academician of Chinese Academy of Sciences in 2011. In 2012, he was appointed as the President of Nanjing Tech University. Now he is the Deputy President and Provost of the Northwestern Polytechnical University. His research interests include flexible electronics, organic optoelectronics, nanoelectronics, and bioelectronics.

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Cite this article:

SONG Jiang,WANG Tengjiao,FENG Tao, et al. Applying Flexible Electronics in the Diagnosis, Treatment and Nursing Care for Diabetes Mellitus: a Review[J]. Materials Reports, 2020, 34(1): 1126-1134.

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http://www.mater-rep.com/EN/10.11896/cldb.19100178 OR http://www.mater-rep.com/EN/Y2020/V34/I1/1126

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