基于有机薄膜晶体管与有机电化学晶体管的生物传感器研究进展

doi:10.11896/cldb.18010190

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Abstract Biosensor is a novel high techno-logy that derived from multidiscipline including biology, chemistry, physics, medicine, and electronic techno-logy. It has vast application in diverse field of the national economy such as food, pharmaceuticals, chemical industry, clinical testing, biomedicine, and environmental monitoring. Featured by high selectivity, high sensitivity, fast analysis speed, low cost, and continuous on-line monitoring in complex systems, especially high degree of automation, miniaturization, and integration, biosensors have developed vigorously and swiftly in recent decades. In the field of biosensors, organic electronic devices exhibit broad application prospects and unparalleled advantages, especially in low-cost, disposable, portable, flexible bending,etc.
In the field of organic electronics,there are two kind of biosensors, namely organic thin film transistors (OTFTs) biosensors and organic electrochemical transistors (OECTs) biosensors, that aroused widespread concerns and interests. OTFTs biosensors are made of all-solid-state film, which is convenient to integrate because of its process simplicity and compatibility with traditional semiconductor processing technology. In addition, OTFTs biosensors possess diversified detection units, which is not limited to the organic semiconductor layer and include gate and source leakage electrodes. At present, high-performance active layer materials like pentacene, poly(3-hexylthiophene) (P3HT), and polyaniline (PANI) have been successfully used in the biosensor. Research work mainly lies in improvements in DNA surface immobilization methods, sensor structure design and sensitivity optimization, and new extended gate structures. There is a certain limitation for the detection in convenience and sensitivity, due to the fact that most of the tests are implemented in a non-aqueous system. For the sake of achieving the detection in aqueous system, OECTs biosensor is proposed. OECTs sensors are not only has the superior in low operating voltage (generally less than 1 V), strong electrochemical activity and capability for working in aqueous environment, but also capable of adjusting the distance between the channel and the gate as required. The emergence of OECTs biosensors has played a vital role in the development of highly specific bioassay test method. At pre-sent, OECTs biosensors have been successfully applied to the detection of deoxyribonucleic acid (DNA), antigens and bacteria. Although the OECT sensor array of the microfluidic system has also successfully detected glucose and lactic acid, it is difficult to develop the OECTs sensor, considering its actual preparation process and detection environment.
In this article, we attempt to provide an overview of biosensors based on organic thin film transistors and organic electrochemical transistors. According to the classification of test objects, the applications of these two biosensors in detecting glucose, DNA, antibody antigens, cells and dopamine are described in detail. meanwhile, their sensing mechanisms and detection capabilities are introduced. It is expected that with the deve-lopment of organic electronic technology, organic transistors will play a more important role in biological detection.

Key words： biosensors organic thin film transistor organic electrochemical transistor sensitivity

Published: 10 April 2019

CLC number:

TP212

Fund:This work was financially supported by the National Natural Science Foundation of China (11704242,11705115), and Shanghai Young Teachers' Training Program for Higher Education (ZZGCD16020)

About author:: Xiaoqian Feng received her B.D. degree in microelectronic manufacturing engineering from Wei Fang University in 2016. She is currently pursuing her m.E. at the Shanghai University of Engineering Science under the supervision of Wen Gu. Her research has focused on the organic thin film transistors and biosensors.Wen Gu received his Ph.D. degree in mechanical engineering from the Shanghai University, in 2015. He is currently a lecturer in Shanghai University of Enginee-ring Science. His research interests are semiconductor devices, including organic field effect transistors and LEDs.

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	FENG Xiaoqian
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	ZHANG Xia
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Cite this article:

FENG Xiaoqian,GU Wen,ZHANG Xia, et al. Advances in Biosensors Based on Organic Thin Film Transistors and Organic Electrochemical Transistors[J]. Materials Reports, 2019, 33(7): 1243-1250.

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http://www.mater-rep.com/EN/10.11896/cldb.18010190 OR http://www.mater-rep.com/EN/Y2019/V33/I7/1243

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