| POLYMERS AND POLYMER MATRIX COMPOSITES |
|
|
|
|
|
| Preparation of Poly(N-isopropylacrylamide) Hydrogel and Its Thermally Induced Aggregation Behavior |
| HU Yaoqiang1,2, CHEN Fajin1, LIU Haining2,3, ZHANG Huifang2,3, WU Zhijian2,3, YE Xiushen2,3
|
1 College of Ocean and Meteorology, Guangdong Ocean University, Zhanjiang 524088;
2 Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources, Chinese Academy of Sciences, Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining 810008;
3 Key Laboratory of Salt Lake Resources Chemistry of Qinghai Province, Xining 810008 |
|
|
|
|
Abstract The PNIPAM hydrogels were prepared by emulsifier-free emulsion polymerization method, using NIPAM as monomer, MBA as crosslinking agent and KPS as initiator. Morphology and molecular structure of PNIPAM were examined by SEM and FTIR measurements. The influences of polymerization time, temperature, concentration, pH, coexisted NaCl and MgCl2 on the thermally induced aggregation behavior were comprehensively investigated. The results indicated that this method is simple and easy to operate, and the obtained hydrogel has an obvious thermal-responsive effect. Its thermally induced aggregation behavior becomes more significant with the extension of polymerization time. The thermally induced aggregation behavior of PNIPAM becomes more obvious with the increase of polymerization time, PNIPAM concentration and coexisted salt concentration, or the decrease of pH.
|
|
Published: 31 July 2018
|
|
|
|
|
1 Tang C, Feller L, Rossbach P, et al. Adsorption and electrically stimulated desorption of the triblock copolymer poly(propylene sulfide-bl-ethylene glycol) (PPS-PEG) from indium tin oxide (ITO) surfaces[J]. Surface Science,2006,600(7):1510.
2 Hu X Y, Chen Y B, Liang H X, et al. Preparation of pressure responsive hollow fiber membrane by melt-spinning of polyurethane-poly(vinylidene fluoride)-poly(ethylene glycol) blends[J]. Materials and Manufacturing Process,2010,25:1018.
3 Gao W W, Chan J M, Farokhzad O C. pH-responsive nanoparticles for drug delivery[J]. Molecular Pharmaceutics,2010,7(6):1913.
4 Saidi L, Vilela C, Oliveira H, et al. Poly(N-methacryloyl glycine)/nanocellulose composites as pH-sensitive systems for controlled release of diclofenac[J]. Carbohydrate Polymers,2017,169:357.
5 Zhang R S, Tang M G, Bowyer A, et al. A novel pH-and ionic-strength-sensitive carboxy methyl dextran hydrogel[J]. Biomate-rials,2005,26(22):4677.
6 Luo Y F, Yu X H. Light and electrically responsive materials based on aligned carbon nanotubes[J]. European Polymer Journal,2016,82:290.
7 Fujishige S, Kubota K, Ando I. Phase transition of aqueous solutions of poly(N-isopropylacrylamide) and poly(N-isopropylmethacrylamide)[J]. The Journal of Physical Chemistry,1989,93(8):3311.
8 Meyer D E, Shin B C, Kong G A, et al. Drug targeting using thermally responsive polymers and local hyperthermia[J]. Journal of Controlled Release,2001,74(1-3):213.
9 Chung J E, Yokoyama M, Yamato M, et al. Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate)[J]. Journal of Controlled Release,1999,62(1-2):115.
10 Chilkoti A, Dreher M R, Meyer D E, et al. Targeted drug delivery by thermally responsive polymers[J]. Advanced Drug Delivery Reviews,2002,54(5):613.
11 Liu Y F, Yang Y L, Wang C, et al. Stimuli-responsive self-assembling peptides made from antibacterial peptides[J]. Nanoscale,2013,5(14):6413.
12 Lou S F, Gao S, Wang W W, et al. Galactose-functionalized multi-responsive nanogels for hepatoma-targeted drug delivery[J]. Nanoscale,2015,7(7):3137.
13 Tokarev I, Minko S. Stimuli-responsive porous hydrogels at Interfaces for molecular filtration, separation, controlled release, and gating in capsules and membranes[J]. Advanced Materials,2010,22(31):3446.
14 Sosnik A, Cohn D. Reverse thermo-responsive poly(ethylene oxide) and poly(propylene oxide) multiblock copolymers[J]. Biomaterials,2005,26(4):349.
15 Ci J L, Kang H L, Liu C G, et al. Thermal sensitivity and protein anti-adsorption of hydroxypropyl cellulose-g-poly(2-(methacryloyloxy) ethyl phosphorylcholine)[J]. Carbohydrate Polymers,2017,157:757.
16 Pelton R H, Chibante P. Preparation of aqueous lattices with N-isopropylacrylamide[J]. Colloids and Surfaces,1986,20(3):247.
17 Zhao X J, Gao Z F. Role of hydrogen bonding in solubility of poly(N-isopropylacrylamide) brushes in sodium halide solutions[J]. Chinese Physics B,2016,25(7):074703.
18 Dong Q J, Qian M J, Luo C H. Phase separation behavior and fluorescence properties of poly(N-isopropylacrylamide) with chalcone side groups in mixed solvents[J]. Journal of Polymer Research,2016,23(2):33.
19 Hiruta Y, Nagumo Y, Suzuki Y, et al. The effects of anionic electrolytes and human serum albumin on the LCST of poly(N-isopropylacrylamide)-based temperature-responsive copolymers[J]. Colloids and Surface B Biointerfaces,2015,132:299.
20 Costa M C M, Silva S M C, Antunes F E. Adjusting the low critical solution temperature of poly(N-isopropyl acrylamide) solutions by salts, ionic surfactants and solvents: A rheological study[J]. Journal of Molecular Liquids,2015,210:113.
21 Li J J, Zhou Y N, Luo Z H. Thermo-responsive brush copolymers with structure-tunable LCST and switchable surface wettability[J]. Polymer,2014,55(25):6552.
22 Grant N C, Cooper A I, Zhang H F. Uploading and temperature-controlled release of polymeric colloids via hydrophilic emulsion-templated porous polymers[J]. ACS Applied Materials and Interfaces,2010,2(5):1400.
23 Pan K, Zhang X W, Cao B. Surface-initiated atom transfer radical polymerization of regenerated cellulose membranes with thermo-responsive properties[J]. Polymer International,2010,59(6):733.
24 Yu Y L, Zhang M J, Xie R, et al. Thermo-responsive monodisperse core-shell microspheres with PNIPAM core and biocompatible porous ethyl cellulose shell embedded with PNIPAM gates[J]. Journal of Colloid and Interface Science,2012,376:97.
25 Kumar S, Dory Y L, Lepage M, et al. Surface-grafted stimuli-responsive block copolymer brushes for the thermo-, photo-and pH-sensitive release of dye molecules[J]. Macromolecules,2011,44(18):7385.
26 Meng T, Xie R, Chen Y C, et al. A thermo-responsive affinity membrane with nano-structured pores and grafted poly(N-isopropylacrylamide) surface layer for hydrophobic adsorption[J]. Journal of Membrane Science,2010,349(1-2):258.
27 Trzebicka B, Robak B, Trzcinska R, et al. Thermosensitive PNIPAM-peptide conjugate-synthesis and aggregation[J]. European Polymer Journal,2013,49(2):499.
28 Lemanowicz M, Kuznik W, Gibas M, et al. Impact of heating me-thod on the flocculation process using thermosensitive polymer[J]. Water Research,2012,46(13):4091.
29 Zhou J H, Chen X, Ma J Z. Synthesis of cationic fluorinated polyacrylate copolymer by RAFT emulsifier-free emulsion polymerization and its application as waterborne textile finishing agent[J]. Dyes and Pigments,2017,139:102.
30 Yang X Y, Tong Y Y, Li Z C, et al. Aggregation-induced microgelation: A new approach to prepare gels in solution[J]. Soft Matter,2011,7(3):978.
31 Wang Q W, Tang H, Wu P Y. Aqueous solutions of poly(ethylene oxide)-poly(N-isopropylacrylamide): Thermosensitive behavior and distinct multiple assembly processes[J]. Langmuir,2015,31(23):6497.
32 Kurzhals S, Gal N, Zirbs R, et al. Aggregation of thermoresponsive core-shell nanoparticles: Influence of particle concentration, dispersant molecular weight and grafting[J]. Journal of Colloid and Interface Science,2017,500:321.
33 Katono H, Maruyama A, Sanui K, et al. Thermo-responsive swel-ling and drug release switching of interpenetrating polymer networks composed of poly(acrylamide-co-butyl methacrylate) and poly (acry-lic acid)[J]. Journal of Controlled Release,1991,16(1-2):215.
34 Tu C W, Kuo S W. Using FTIR spectroscopy to study the phase transitions of poly(N-isopropylacrylamide) in tetrahydrofuran-d8/D2O[J]. Journal of Polymer Research,2014,21(6):476.
35 Singh R, Deshmukh S A, Kamath G, et al. Controlling the aqueous solubility of PNIPAM with hydrophobic molecular units[J]. Computational Materials Science,2017,126:191.
36 Lemanowicz M, Sulc R, Gierczycki A, et al. Impact of the heating rate on the thermosensitive aggregation: Experimental results and mathematical model[J]. Chemical Engineering Research and Design,2015,98:168.
37 Lemanowicz M. Thermosensitive aggregation under conditions of repeated heating-cooling cycles[J]. International Journal of Mineral Processing,2015,144:26.
38 Min M H, Shen L D, Hong G S, et al. Micro-nano structure poly(ether sulfones)/poly(ethyleneimine) nanofibrous affinity membranes for adsorption of anionic dyes and heavy metal ions in aqueous solution[J]. Chemical Engineering Journal,2012,197:88.
39 Wang T, Turhan M, Gunasekaran S. Selected properties of pH-sensitive, biodegradable chitosan-poly(vinyl alcohol) hydrogel[J]. Polymer International,2004,53(7):911.
40 Hu Y Q, Guo T, Ye X S, et al. Dye adsorption by resins: Effect of ionic strength on hydrophobic and electrostatic interactions[J]. Chemical Engineering Journal,2012,228:392.
41 Jamesh M I, Wu G S, Zhao Y, et al. Electrochemical corrosion behavior of biodegradable Mg-Y-RE and Mg-Zn-Zr alloys in Ringer’s solution and simulated body fluid[J]. Corrosion Science,2015,91:160. |
|
|
|
渝公网安备50019002502923号 © Editorial Office of Materials Reports.
2018, Vol. 32 
