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CLDB  2017, Vol. 31 Issue (13): 151-155    https://doi.org/10.11896/j.issn.1005-023X.2017.013.020
  生物医用材料 |
新型钇-羟基磷灰石骨水泥的制备及性能研究*
漆小鹏, 李文, 罗远方, 杨辉
江西理工大学材料科学与工程学院,赣州 341000
Preparation and Properties of a Novel Yttrium-hydroxyapatite Cement
QI Xiaopeng, LI Wen, LUO Yuanfang,YANG Hui
School of Materials Science and Engineering, Jiangxi University of Science and Technology, Ganzhou 341000
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摘要 利用高温固相法合成了掺钇的磷酸四钙,将其与无水磷酸氢钙以物质的量比1∶1混合制备了钇-羟基磷灰石骨水泥(Y-HAC)。结果表明:少量钇的掺入不会改变骨水泥的水化产物,骨水泥能正常水化,水化产物为弱结晶羟基磷灰石。与纯羟基磷灰石骨水泥(HAC)相比,Y-HAC的湿态抗压强度提高了120%,干态抗压强度提高了85%。同时,钇的掺入还提高了材料的孔隙率。Y-HAC的微观结构呈现紧密结合的片状羟基磷灰石结晶体。体外释放实验表明,钇的释放量极低,说明钇-羟基磷灰石骨水泥具有较好的稳定性。Y-HAC是一种很有前途的骨组织修复材料,并可用于载药材料和骨组织工程支架材料。
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漆小鹏
李文
罗远方
杨辉
关键词:    羟基磷灰石骨水泥  抗压强度  骨修复    
Abstract: The tetracalcium phosphate (TTCP) doped with yttrium was prepared by high temperature solid state method. Then the TTCP doped with yttrium was mixed with dicalcium phosphate anhydrous (DCPA) at a molar ratio of 1∶1 to form ytt-rium-hydroxyapatite cement (Y-HAC). The results showed that the reaction product of Y-HAC is poorly crystalline hydroxyapatite, indicating that the addition of small amount of yttrium has not changed the hydration reaction of hydroxyapatite cement (HAC). The wet compressive strength of Y-HAC increased 120% and dry compressive strength increased 85%, compared with that of HAC. The porosity of specimens has been augmented with the doping of yttrium. There exists some changes in crystallization morphology of Y-HAC, emerging many closely combined flaked crystals and construct a three-dimensional network structure. The in-vitro release experiment indicated that Y-HACs have very low release of yttrium. The Y-HAC might be a potential material for bone substitute, drug-loaded and bone tissue engineering.
Key words:  yttrium    hydroxyapatite cement    compressive strength    bone repair
               出版日期:  2017-07-10      发布日期:  2018-05-04
ZTFLH:  R318.08  
基金资助: * 江西理工大学科研基金重点课题(NSFJ2014-K10)
作者简介:  漆小鹏:男,1977年生,博士,副教授,硕士研究生导师,研究方向为生物医用材料 E-mail:81714680@qq.com
引用本文:    
漆小鹏, 李文, 罗远方, 杨辉. 新型钇-羟基磷灰石骨水泥的制备及性能研究*[J]. CLDB, 2017, 31(13): 151-155.
QI Xiaopeng, LI Wen, LUO Yuanfang, YANG Hui. Preparation and Properties of a Novel Yttrium-hydroxyapatite Cement. Materials Reports, 2017, 31(13): 151-155.
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http://www.mater-rep.com/CN/10.11896/j.issn.1005-023X.2017.013.020  或          http://www.mater-rep.com/CN/Y2017/V31/I13/151
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