金纳米材料光学传感快速检测方法研究要点初探

doi:10.11896/cldb.20050221

材料导报

2021, Vol. 35

Issue (19): 19099-19115 https://doi.org/10.11896/cldb.20050221

金属与金属基复合材料

金纳米材料光学传感快速检测方法研究要点初探

赵笙良^1,2, 刘飞燕¹, 陈丽琼¹

1 深圳技术大学新材料与新能源学院,深圳 518118
2 深圳大学应用技术学院,深圳 518061

Review on the Key Points of the Rapid Detection Methods Based on Gold Nanomaterial Optical Sensors

ZHAO Shengliang^1,2, LIU Feiyan¹, CHEN Liqiong¹

1 College of New Materials and New Energies, Shenzhen Technology University, Shenzhen 518118, China
2 College of Applied Technology, Shenzhen University, Shenzhen 518061, China

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摘要基于金纳米材料光学性能优良、稳定性高以及易于表面功能化等特点而建立的纳米金光学传感检测方法,具有灵敏度高、准确、易操作、可视化和成本低等优点。金纳米材料类传感器是利用功能化纳米金与目标物之间发生相互作用,使得金纳米颗粒的尺寸、形状和聚集状态发生改变,从而引起溶液颜色、荧光和散射强度发生变化,为目标物的快速检测提供了出色的测定平台。
为更好地介绍金纳米材料在现代检测领域的重要作用,本文首先总结了近年来出现的四种常见纳米金光学传感检测方法:纳米金聚集光学传感法、纳米金刻蚀光学传感法、纳米金荧光光学传感法、纳米金散射光学传感法。通过介绍这些方法的检测原理,探讨了其在化学、生物和环境领域的发展及应用。随后,通过分析四种策略的设计思路,初步总结出七个关于开发纳米金光学传感检测技术实验要点,分别是纳米金的合成与表面功能化、溶液pH、反应温度和反应时间、选择性、体系检出限、方法准确性、体系可重复利用性。通过详尽分析这些要点的重要性,为接下来从事相关领域研究的科研工作者提供实验设计思路和经验。
最后,本文还探讨了目前基于纳米金光学传感检测方法所面临的一些主要挑战,并展望了该类方法在未来的发展方向。例如,通过将该类方法与智能手机、层析试纸条等技术相结合,实现检测过程的简单化、便携化。总体来说,基于金纳米材料的光学传感检测方法具有良好的发展前景。

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	赵笙良
	刘飞燕
	陈丽琼

关键词: 纳米金合成法功能化光学传感快速检测

Abstract: Based on the excellent optical properties, good stability and easy surface functionalization of gold nano-materials, the nano-gold optical sen-sing detection method is established, which has the advantages of high sensitivity, rapid detection, easy operation, visualization, and low cost. This type of sensor makes use of the interaction between functionalized gold nanoparticles and the target to show different colors, fluorescence quenching and scattering intensity changes due to the change of size, shape and aggregation state of gold nanoparticles, which provides an excellent detection platform for the rapid detection of the target.
In this review, four common nano-gold optical sensing detection methods have been summarized to better introduce the important role of gold nanomaterials in the modern detection field, including nano-gold aggregation optical sensing method, nano-gold etching optical sensing method, nano-gold fluorescence optical sensing method, and nano-gold scattering optical sensing method. Through introducing the detection principles of these different strategies, the development and applications of nano-gold optical sensors in chemical, biological and environmental fields are discussed. Subsequently, through analyzing these four methods' experimental design ideas, seven points for the development of nano-gold optical sensing method are preliminarily summarized, namely: gold nanoparticles synthesis and surface functionalization, solution pH, reaction temperature and reaction time, selectivity, system detection limit, method accuracy, and system reusability. Through analyzing the importance of these experimental points, it will provide scientific researchers with reference of experimental design ideas and experience.
Finally, this review discusses several challenges of current nano-gold optical sensing detection methods and forecasts its' future development direction. For example, the technologies of smart phones and immunochromatographic strips can be combined with such methods to realize the simplification and portability in the process of detection. In general, it will have a good development prospect for the optical sensing detection method based on gold nanomaterials.

Key words: gold nanoparticles synthesis method functionalization optical sensor rapid detection

出版日期: 2021-10-10 发布日期: 2021-11-03

ZTFLH:

TB383

基金资助: 广东省普通高校重点领域(乡村振兴)项目(2020ZDZX1009);深圳市科技计划基础研究面上项目(JCYJ20190813103601660);深圳技术大学自制实验仪器设备基金项目资助(2020XZY009)

通讯作者: chenliqiong@sztu.edu.cn

作者简介: 赵笙良,2018年6月毕业于中北大学,获得工学学士学位。现为深圳大学应用技术学院硕士研究生,在陈丽琼教授的指导下进行研究。目前主要研究领域为纳米金可视化快速检测方法研究。
陈丽琼,深圳技术大学新材料与新能源学院教授、硕士研究生导师。2000年6月份本科毕业于中山大学化学与化学工程学院。2009年6月在中山大学化学与化学工程学院获得博士学位。2003—2010年就职于深圳清华大学研究院新材料与生物医药研究所,任工程师/实验室副主任;2010—2017年就职于深圳市计量质量检测研究院化工产品检测所任实验室主任;2018年至今,就职于深圳技术大学新材料与新能源学院,教授。主要从事纳米材料的可控制备与分析测试应用、快速检测技术与装置、仪器分析测试与标准方面的研究。近年来,一直从事纳米材料制备与应用、材料质量检测与标准化研究,发表学术论文10多篇,包括Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy、Food Analytical Methods等。主持参与2项国际标准、8项国家标准、4项团体标准的制修订;获授权发明专利8项、科研奖项2项;获“玩具标准化突出贡献专家”荣誉。

引用本文:

赵笙良, 刘飞燕, 陈丽琼. 金纳米材料光学传感快速检测方法研究要点初探[J]. 材料导报, 2021, 35(19): 19099-19115.
ZHAO Shengliang, LIU Feiyan, CHEN Liqiong. Review on the Key Points of the Rapid Detection Methods Based on Gold Nanomaterial Optical Sensors. Materials Reports, 2021, 35(19): 19099-19115.

链接本文:

http://www.mater-rep.com/CN/10.11896/cldb.20050221 或 http://www.mater-rep.com/CN/Y2021/V35/I19/19099

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